3-bromo-6-methylpyridazine
- Product Name
- 3-bromo-6-methylpyridazine
- CAS No.
- 65202-58-6
- Chemical Name
- 3-bromo-6-methylpyridazine
- Synonyms
- 3-bromo-6-methylpyridazine;6-Methyl-3-broMopyridazine;Pyridazine, 3-broMo-6-Methyl-;3-bromo-6-methylpyridazine ISO 9001：2015 REACH;3-bromo-6-methylpyridazine 6-Methyl-3-broMopyridazine
- CBNumber
- CB62022512
- Molecular Formula
- C5H5BrN2
- Formula Weight
- 173.01
- MOL File
- 65202-58-6.mol
3-bromo-6-methylpyridazine Property
- Boiling point:
- 285.0±20.0 °C(Predicted)
- Density
- 1.596±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 1.26±0.10(Predicted)
- form
- Solid
- color
- Dark Brown
- InChI
- InChI=1S/C5H5BrN2/c1-4-2-3-5(6)8-7-4/h2-3H,1H3
- InChIKey
- RACIHBXDZONTQJ-UHFFFAOYSA-N
- SMILES
- C1(Br)=NN=C(C)C=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B688315
- Product name
- 3-Bromo-6-methylpyridazine
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- J51013
- Product name
- 3-Bromo-6-methylpyridazine
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FB140384
- Product name
- 3-Bromo-6-methylpyridazine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 074604
- Product name
- 3-Bromo-6-methylpyridazine
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB140384
- Product name
- 3-Bromo-6-methylpyridazine
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
3-bromo-6-methylpyridazine Chemical Properties,Usage,Production
Uses
3-Bromo-6-methylpyridazine is used as a reagent in the synthesis of piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans. 3-Bromo-6-methylpyridazine is also used in the preparation of cyclohexyl fluoropyrimidinyl benzamides as CNS penetrable P2X7 receptor antagonists.
Synthesis
13327-27-0
65202-58-6
6-Methyl-3(2H)-pyridazinone (18 g, 163.44 mmol) was mixed with phosphorus tribromide oxide (93.8 g, 327.6 mmol) and the reaction was stirred at 70 °C overnight. Upon completion of the reaction, the reaction mixture was cooled to 40 °C and quenched by slowly pouring it into ice water. Subsequently, the reaction mixture was neutralized with saturated sodium bicarbonate solution (20 mL) and extracted with dichloromethane (100 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 3-bromo-6-methylpyridazine (8 g, 31% yield). The product was detected by LCMS (ESI), m/z: 173 [M + 1]+. 1H NMR (chloroform-d, Bruker Avance 400MHz) data were as follows: δ 7.86-7.88 (d, 1H, J = 8Hz), 7.52-7.54 (d, 1H, J = 8Hz), 2.55 (s, 3H).
References
[1] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0136; 0137
[2] Patent: WO2010/36998, 2010, A2. Location in patent: Page/Page column 184
3-bromo-6-methylpyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-bromo-6-methylpyridazine manufacturers
- Product
- 3-Bromo-6-methylpyridazine 65202-58-6
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- 3-bromo-6-methylpyridazine 6-Methyl-3-broMopyridazine 65202-58-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-14
- Product
- 3-bromo-6-methylpyridazine 65202-58-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-08