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N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide

Product Name
N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide
CAS No.
544681-96-1
Chemical Name
N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide
Synonyms
3i-1000;GATA4-IN-3;3i-1000 (3i 1000);GATA4-NKX2-5-IN-1;GATA4-NKX2-5-IN-1 ，S0432;GATA4-IN-3 (GATA4 inhibitor 3);GATA4-NKX2-5-IN-1, 10 mM in DMSO;N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide;GATA4 NKX2 5 IN 1,inhibit,GATA-4-NKX2-5-IN-1,Inhibitor,GATA4NKX25IN1;4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-
CBNumber
CB62027234
Molecular Formula
C21H23N3O2
Formula Weight
349.43
MOL File
544681-96-1.mol
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N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide Property

Boiling point:
486.6±45.0 °C(Predicted)
Density 
1.176±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 70 mg/mL (200.33 mM);Ethanol: 9 mg/mL (25.76 mM)
pka
11.56±0.70(Predicted)
form 
Solid
color 
Off-white to pale purple
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

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N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide Chemical Properties,Usage,Production

Uses

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression[1].

References

[1] V?lim?ki MJ, et al. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem. 2017 Sep 28;60(18):7781-7798. DOI:10.1021/acs.jmedchem.7b00816

N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide Suppliers

China 27 The Netherlands 1 United States 4 Global 32
TargetMol Chemicals Inc.
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544681-96-1, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamideRelated Search:


  • GATA4-IN-3 (GATA4 inhibitor 3)
  • GATA4-IN-3
  • N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide
  • GATA4-NKX2-5-IN-1
  • N-[4-(Diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
  • 3i-1000
  • GATA4 NKX2 5 IN 1,inhibit,GATA-4-NKX2-5-IN-1,Inhibitor,GATA4NKX25IN1
  • 4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-
  • GATA4-NKX2-5-IN-1, 10 mM in DMSO
  • 3i-1000 (3i 1000)
  • GATA4-NKX2-5-IN-1 ，S0432
  • 544681-96-1