2-Hydroxypropyl-β-cyclodextrin

ChemicalBook > CAS DataBase List > 2-Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-β-cyclodextrin

Structure

Product Name: 2-Hydroxypropyl-β-cyclodextrin
CAS No.: 128446-35-5
Chemical Name: 2-Hydroxypropyl-β-cyclodextrin
Synonyms: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;(2-Hydroxypropyl)-β-cyclodextrin;Hydroxypropyl-b-Cyclodextrin;HP-beta-CD;beta-cyclodextrin,2-hydroxypropylether;(2-Hydroxypropyl)-beta-cyclode;HPBCD/HPCD;)-beta-cycL;CAVASOL(R)W7;Cavasol? W7 HP
CBNumber: CB6204503
Molecular Formula: C63H112O42
Formula Weight: 1541.54
MOL File: 128446-35-5.mol

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2-Hydroxypropyl-β-cyclodextrin Property

Melting point:: 278 °C (dec.)
Boiling point:: 400℃
Density: 1.05 at 20.3℃
refractive index: 125 ° (C=1, H2O)
storage temp.: room temp
solubility: H₂O: 45 % (w/v)
form: solution (clear, colorless)
color: White to slightly yellow
optical activity: [α]26/D +139°, c = 1 in H2O
Water Solubility: Soluble in water.
InChIKey: ODLHGICHYURWBS-FOSILIAISA-N
LogP: -4 at 20℃
Surface tension: 63.6-65mN/m at 1g/L and 22℃
EPA Substance Registry System: .beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: GU2293332
TSCA: Yes
HS Code: 29400090
Toxicity: mouse,LD,intravenous,> 5gm/kg (5000mg/kg),Journal of Pharmaceutical Sciences. Vol. 84, Pg. 1223, 1995.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 332593
Product name: (2-Hydroxypropyl)-β-cyclodextrin
Purity: average Mw ~1,380
Packaging: 1kg
Price: $793
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1329709
Product name: Hydroxypropyl betadex
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $491
Updated: 2024/03/01

TCI Chemical

Product number: H0979
Product name: Hydroxypropyl-β-cyclodextrin
Packaging: 25g
Price: $138
Updated: 2024/03/01

TCI Chemical

Product number: H0979
Product name: Hydroxypropyl-β-cyclodextrin
Packaging: 100g
Price: $251
Updated: 2024/03/01

Alfa Aesar

Product number: H31133
Product name: (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480
Packaging: 5g
Price: $47.5
Updated: 2024/03/01

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2-Hydroxypropyl-β-cyclodextrin Chemical Properties,Usage,Production

Structure

2-Hydroxypropyl-β-cyclodextrins (HPβCDs) are synthesized by condensation between β-cyclo-dextrin (βCD) and propylene oxide. Structure of 2-hydroxypropyl-β-cyclodextrin (HPβCD) where R = H or CH2-CHOH-CH3 is shown below. There are 21 (red) hydroxyl groups on βCD, which are potential substitution sites for the condensation reaction with propylene oxide to yield various species of HPβCD with different degrees of substitution depending upon how many sites are substituted[3].

Chemical Properties

White to slightly yellow powder

Chemical Properties

Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

Uses

enteric coating, sustained release formulations, buccal and transdermal drug delivery

Uses

2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis

Uses

2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.

Production Methods

Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.

General Description

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins.

Pharmaceutical Applications

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

Biological Activity

Cell treatment with HPβCD results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in the enhancement of the cellular autophagic clearance capacity. HPβCD administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder. Interestingly, HPβCD-mediated activation of autophagy was found not to be associated with activation of apoptotic pathways[2].

Side effects

2-Hydroxypropyl-β-cyclodextrin (HP-beta-CD) has been shown to be well tolerated in humans, with the main adverse event being diarrhoea and there have been no adverse events on kidney function, documented to date[1].

Safety

The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.

storage

Store in well-closed containers.

Regulatory Status

Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

References

[1] Sarah Gould, Robert C. Scott. “2-Hydroxypropyl-β-cyclodextrin (HP-β-CD): A toxicology review.” Food and Chemical Toxicology 43 10 (2005): Pages 1451-1459.
[2] Wensi Song. “2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy.” The Journal of Biological Chemistry (2014): 10211–22.
[3] Alfred L Yergey. “Correction: Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1.” PLoS ONE (2018): e0192424.

2-Hydroxypropyl-β-cyclodextrin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Hydroxypropyl-β-cyclodextrin manufacturers

Wuhan Fortuna Chemical Co.,Ltd

Product: 2-Hydroxypropyl-β-cyclodextrin 128446-35-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20tons
Release date: 2024-08-10

Watson Biotechnology Co.,Ltd

Product: 2-Hydroxypropyl-β-cyclodextrin((HP-β-CD) 128446-35-5
Price: US $120.00-12.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-07-18

HebeiShuoshengImportandExportco.,Ltd

Product: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN 128446-35-5
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-09

128446-35-5, 2-Hydroxypropyl-β-cyclodextrinRelated Search:

HYDROXYPROPYL-BETA-CYCLODEXTRIN Hydroxypropyl cellulose Hydroxypropyl methyl cellulose (2-Hydroxypropyl)-γ-cyclodextrin 2-hydroxypropyl-α-cyclodextrin Hydroxypropyl methylcellulose phthalate β-Cyclodextrin D-(+)-DIGITOXOSE 6-Deoxy-L-glucose L-SORBITOL METHYL-Β-D-ARABINO- PYRANOSIDE 2-Hydroxypropyl-β-cyclodextrin D-Arabinpyranose Dextrin beta-Cyclodextrin hydrate SUCCINYL-(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN .alpha.-D-Arabinopyranoside, methyl D-TALITOL

beta-cyclodextrin,2-hydroxypropylether

(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1340

(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca 1400

Hydroxypropyl-beta-cyclodextrin,97%

(2-Hydroxypropyl)-beta-cyclode

(2-Hydroxypropyl)-beta-cyclodextrin, avge. MW ca 1400

(2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480

(2-Hydroxypropyl)-β-cyclodextrin ,97%

Hydroxypropyl Betadex (200 mg)

Hydroxypropyl-beta-cyclodextrin, 97% 100GR

Hydroxypropyl-beta-cyclodextrin, 97% 25GR

(2-Hydroxypropyl)-^b-cyclodextrin, MW ca 1250-1480

β-Cyclodextrin 2-Hydroxypropyl Ethers

HPBCD/HPCD

(2-Hydroxypropyl)-beta-cyclodextrin ,EP

Hydroxypropyl-b-cyclodextrin EP

Hydroxypropyl-b-cyclodextrin USP

(2-Hydroxypropyl)-beta-cyclodextrin average Mw ~1,380

(2-Hydroxypropyl)-beta-cyclodextrin average Mw ~1,460

(2-Hydroxypropyl)-beta-cyclodextrin, 97+%

HP-beta-CD

CAVASOL(R)W7

(2-Hydroxypropyl)-β-cyclodextrin, avge. MW ca 1340

(2-Hydroxypropyl)-β-cyclodextrin, avge. MW ca 1400

HYDROXYPROPYL B-CYCLODEXTRIN USP, NF

Cavasol? W7 HP

2-Hydroxypropyl-&beta

(2-Hydroxypropyl)-beta-cyclodextrin average Mw ~1,540

(2-Hydroxypropyl)-beta-cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany

2-hydroxypropyl-beta-cyclodextirn

Hydroxypropyl-β-cyclodextrin(HP-β-CD)

(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)

hydropropyl beta cyclodextrin

HP-β-CD, hydroxypropyl-β-cyclodextrin

beta-hydroxypropylcyclodextrin

(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN

(2-Hydroxypropyl)-β-cyclodextrin

2-Hydroxypropyl-B-Cyclodextrin

2-HYDROXYPROPYL-B-CYCLODEXTRIN CELLCULTU RE TESTED

HYDROXYPROPYL-BETA-CYCLODEXTRIN (MS = 0. 8)

(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN (MS=1.0)

HYDROXYPROPYL-BETA-CYCLODEXTRIN, MS = 0. 6

Hydroxypropyl-b-Cyclodextrin

HPBCD\/(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN

injection hydroxypropyl-beta-cyclodextrin

Hydroxypropyl beta cyclodextrin aqueous solution

Pharmaceutical grade hydroxypropyl betadex

Injection grade hydroxypropyl betadex

Technical grade hydroxypropyl beta cyclodextrin

Hydroxypropyl Beta Cyclodextrin sythetic

(2-Hydroxypropyl)-beta-cyclodextrin (DS~4.5)

Hydroxypropyl-beta-Cyclodextrin,Hydroxypropyl betadex

2-Hydroxypropyl-beta-cyclodextrin in stock Factory

(94035-02-6) hydroxypropyl-beta-cyclodextrin

2-hydroxypropylether-beta-cyclodextrin

Hydroxypropyl betadex, 2-Hydroxypropyl-b-cyclodextrin

(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN，Hydroxypropyl-beta-cyclodextrin

Hydroxypropylbetadex CRS