ChemicalBook > CAS DataBase List > Z-PHE-ALA-OH

Z-PHE-ALA-OH

Product Name
Z-PHE-ALA-OH
CAS No.
21881-18-5
Chemical Name
Z-PHE-ALA-OH
Synonyms
Z-PHE-ALA;Z-PHE-ALA-OH;CBZ-L-PHE-ALA;N-CBZ-PHE-ALA;Cbz-Phe-Ala-OH;CBZ-L-PHE-L-ALA;Cbz-L-Phe-L-Ala-OH;Z-PHE-ALA-OH USP/EP/BP;N-carbobenzyloxy-Phe-Ala;Z-Phe-Ala-OH≥ 99% (HPLC)
CBNumber
CB6204765
Molecular Formula
C20H22N2O5
Formula Weight
370.4
MOL File
21881-18-5.mol
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Z-PHE-ALA-OH Property

Melting point:
151-154 °C
storage temp. 
Sealed in dry,2-8°C
solubility 
methanol: ~50mg/mL, almost clear, almost colorless
Boiling point:
666.1±55.0 °C(Predicted)
Density 
1.253±0.06 g/cm3(Predicted)
pka
3.50±0.10(Predicted)
form 
powder
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
P998453
Product name
Z-Phe-Ala-OH
Packaging
100mg
Price
$75
Updated
2021/12/16
Usbiological
Product number
287803
Product name
Z-Phe-Ala-OH
Packaging
2g
Price
$343
Updated
2021/12/16
Ark Pharm
Product number
AK-48037
Product name
Z-Phe-Ala-OH
Purity
95%
Packaging
1g
Price
$20
Updated
2021/12/16
Chem-Impex
Product number
05219
Product name
Z-Phe-Ala-OH
Purity
≥ 99% (HPLC)
Packaging
1G
Price
$25.9
Updated
2021/12/16
Matrix Scientific
Product number
094129
Product name
Z-Phe-Ala
Purity
95+%
Packaging
1g
Price
$95
Updated
2021/12/16
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Z-PHE-ALA-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Sensitive substrate for cathepsin A.

Synthesis

3397-32-8

56-41-7

3338-39-4

The general procedure for the synthesis of the compound (CAS:3338-39-4) from (S)-2,5-dioxopyrrolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate and L-alanine was as follows: with reference to the method of Itoh [M. Itoh, Chem. Pharm. Bull., 20, 664 (1972)], to L- alanine (18 mmol, 1.60 g) dissolved in 200 mL of a 1:1 dioxane-water mixture to triethylamine (36 mmol, 5.0 mL). Solid carbon dioxide tablets were added under stirring conditions until the solution pH reached 8. Subsequently, N-Benzyloxycarbonyl-L-phenylalanine N-hydroxysuccinimide ester (18 mmol, 7.13 g) was added under stirring at room temperature. After 16-20 hours of reaction, the reaction mixture was acidified by slow addition of 1N HCl followed by extraction with ethyl acetate. The organic phase was separated, washed sequentially with water (twice) and brine, dried over MgSO4, concentrated by rotary evaporation and dried under high vacuum to give 6.19 g (93% yield) of N-Benzyloxycarbonyl-L-phenylalanyl-L-alanine as a white solid with a melting point of 160-164 °C (literature value: 165 °C; G.R. Pettit, 'Synthetic Peptides', Vol. 1, p. 141 (1970)). Using similar methods, the following compounds of formula (2) can be prepared according to the procedure described in Preparation 1.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6230 - 6237
[2] Patent: US5055451, 1991, A
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 3, p. 1071 - 1078

Z-PHE-ALA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-PHE-ALA-OH Suppliers

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View Lastest Price from Z-PHE-ALA-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Cbz-Phe-Ala-OH 21881-18-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-19

21881-18-5, Z-PHE-ALA-OHRelated Search:

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  • CBZ-L-PHE-ALA
  • CBZ-L-PHE-L-ALA
  • Z-PHE-ALA-OH
  • Z-PHE-ALA
  • Z-L-PHENYLALANYL-L-ALANINE
  • N-CBZ-PHE-ALA
  • N-CARBOBENZOXY-L-PHENYLALANYL-L-ALANINE
  • N-BENZYLOXYCARBONYL-L-PHENYLALANYL-L-ALANINE
  • N-carbobenzyloxy-Phe-Ala
  • N-Cbz-Phe-Ala, Z-L-phenylalanyl-L-alanine
  • Cbz-L-Phe-L-Ala-OH
  • Z-Phe-Ala-OH≥ 99% (HPLC)
  • (S)-2-((S)-2-(((Benzyloxy)carbonyl)aMino)-3-phenylpropanaMido)propanoic acid
  • Cbz-Phe-Ala-OH
  • L-Alanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-
  • Z-PHE-ALA-OH USP/EP/BP
  • N-Cbz-L-phenylalanyl-L-alanine
  • (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoic acid - [B91595]
  • 21881-18-5
  • C6H5CH2CHNHCOOCH2C6H5CONHCHCH3COOH
  • Amino Acid Derivatives