ChemicalBook > CAS DataBase List > [H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2
[H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2
- Product Name
- [H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2
- CAS No.
- 940291-10-1
- Chemical Name
- [H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2
- Synonyms
- IDR-1;KSRIVPAIPVSLL;Anti-Infective Peptides;Innate Defense-Regulator Peptide;Innate defense regulator peptide-1;IDR-1, Innate Defense-Regulator Peptide;H-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-NH2;(2S)-1-formyl-N-[(2S)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide,propane;[H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2;L-Leucinamide, L-lysyl-L-seryl-L-arginyl-L-isoleucyl-L-valyl-L-prolyl-L-alanyl-L-isoleucyl-L-prolyl-L-valyl-L-seryl-L-leucyl-
- CBNumber
- CB62097684
- Molecular Formula
- C65H118N18O15
- Formula Weight
- 1391.74
- MOL File
- 940291-10-1.mol
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[H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2 Property
- storage temp.
- −20°C
- form
- Solid
- color
- White to off-white
- Sequence
- H-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-NH2
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[H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2 Chemical Properties,Usage,Production
Uses
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release[1][2].
References
[1] Monisha G Scott, et al. An Anti-Infective Peptide That Selectively Modulates the Innate Immune Response. Nat Biotechnol. 2007 Apr;25(4):465-72. DOI:10.1038/nbt1288
[2] Man Hou, et al. Antimicrobial Peptide LL-37 and IDR-1 Ameliorate MRSA Pneumonia in Vivo. Cell Physiol Biochem. 2013;32(3):614-23. DOI:10.1159/000354465
[H]-Lys-Ser-Arg-Ile-Val-Pro-Ala-Ile-Pro-Val-Ser-Leu-Leu-[NH2], Innate defense regulator peptide-1, KSRIVPAIPVSLL-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
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