PRL-8-53
- Product Name
- PRL-8-53
- CAS No.
- 51352-87-5
- Chemical Name
- PRL-8-53
- Synonyms
- PRL-8-53;PRL-8053;PRL-8-53 HCL;PRL-8-53 CAS 51352-87-5;PRL-8-53 (hydrochloride);PRL-8-53 (HCL)(Phosphate);Methyl 3-(2-(benzyl(methyl);PRL-8-53 PRL-8-53 Nootropics;Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride
- CBNumber
- CB62155834
- Molecular Formula
- C18H22ClNO2
- Formula Weight
- 319.82578
- MOL File
- 51352-87-5.mol
PRL-8-53 Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 30 mg/ml DMSO: 30 mg/ml Ethanol: 30 mg/ml PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- InChI
- InChI=1S/C18H21NO2.ClH/c1-19(14-16-7-4-3-5-8-16)12-11-15-9-6-10-17(13-15)18(20)21-2;/h3-10,13H,11-12,14H2,1-2H3;1H
- InChIKey
- HLBBSWSJLPLPRU-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(CCN(CC2=CC=CC=C2)C)=C1.[H]Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26208
- Product name
- PRL-8-53 (hydrochloride)
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 7146AB
- Product name
- Methyl3-(2-(benzyl(methyl)amino)ethyl)benzoatehydrochloride
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CHM0308019
- Product name
- METHYL-3-(2-(BENZYL(METHYL)AMINO)ETHYL)BENZOATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.46
- Updated
- 2021/12/16
- Product number
- 7146AB
- Product name
- Methyl3-(2-(benzyl(methyl)amino)ethyl)benzoatehydrochloride
- Packaging
- 5g
- Price
- $630
- Updated
- 2021/12/16
- Product number
- 61-5665
- Product name
- methyl3-(2-(benzyl(methyl)amino)ethyl)benzoatehydrochloride
- Purity
- 95+%
- Packaging
- 0.25g
- Price
- $750
- Updated
- 2021/12/16
PRL-8-53 Chemical Properties,Usage,Production
Description
PRL-8-53 is an experimental compound which many believe to be one of the most effective memory boosters available.It is a nootropic research chemical derived from benzoic acid and phenylmethylamine with memory-enhancing effects, used in neuroscience research related to memory enhancement and protection against memory impairment.
History
The drug name of PRL-8-53 is methyl 3-2-benzyl methyl amino ethyl benzoate. It is a promising supplement that was developed in 1972 by Dr. Nikolaus Hansl at Creighton University.
Rumors and a few documents revealed that Dr. Hansl, PRL-8-147, also created a stronger version of PRL-8-53.
In 1978, Dr. Hansl conducted a human study where volunteers doubled their memory with a single dose.
This discovery made PRL-8-53 the most talked-about nootropics in the market.
Neurohackers even tagged it as a powerful supplement that boosts memory formation, retention, and recall improving the overall cognitive function.
Uses
in medicine used in neuroscience research related to memory enhancement and protection against memory impairment.
benefits
Studies have shown that the oral supplement PRL-8-53 improves avoidance learning in rats. Subsequently PRL-8-53 was subjected to a human study in which each participant ingested placebo and PRL-8-53 at different times, and the results confirmed the memory-enhancing effects of using PRL-8-53 supplementation in people over 30 years of age or with poor short-term memory, with improved recall of verbal information, and was well-tolerated, with no side effects observed.
Biological Functions
PRL-8-53 (hydrochloride) is an analytical reference standard that is categorized as a phenethylamine and a nootropic. This product is intended for research and forensic applications.
Mode of action
The exact mechanism of action of PRL-8-53 remains unknown. Doses up to 200 mg/kg are not observed to have stimulant properties, and a dosage of 20 mg/kg does not potentiate the effects of dextroamphetamine in rats. It displays possible cholinergic properties, and potentiates dopamine while partially inhibiting serotonin. PRL-8-53 reverses the catatonic and ptotic effects of reserpine.
Toxicity evaluation
PRL-8-53 is relatively non-toxic, with an oral LD50 in mice of 860 mg/kg, giving the drug a high therapeutic index. Doses above 8 mg/kg have brief hypotensive effects in canines. High doses depress motor activity in the rat and mouse, with the ED50 for a 50% reduction in motor activity of mice at 160 mg/kg. PRL-8-53 displays spasmolytic effects.
Clinical claims and research
The only human study on PRL-8-53 indicates that it may significantly boost memory, particularly in older people. ?
The double-blind study used word memorization as a measure, testing the participants’ ability to recall a list of 12 one-syllable words, first to establish a baseline and then again after ingesting PRL-8-53 or a placebo. The subjects were tested on their ability to recall the words 24 hours after hearing them and then again one week later.
The study results indicate that participants who had higher baseline scores showed the least improvement after ingesting PRL-8-53, while subjects who had demonstrated poorer initial memory or who were over 30 years of age showed significant improvement in recall.
Hansl described the effect on the older participants as follows:
“This group was age 30 or older. As might be expected, rote memory did not come as easily to this group as the younger students. The average retention after 24 hours when on placebo was just under three words out of a possible 12. The average retention after one week was two words. However, the same subjects, when learning subsequent to drug administration, retained an average of 5.85 words after 24 hours and 5.25 words after one week. Again the increases were statistically significant. The improvement expressed in percent of placebo performance was 108% for the 24-hour test and 152% for the one-week recall.”
PRL-8-53 Preparation Products And Raw materials
Raw materials
Preparation Products
PRL-8-53 Suppliers
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View Lastest Price from PRL-8-53 manufacturers
- Product
- PRL-8-53 51352-87-5
- Price
- US $100.00-80.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2024-03-20
- Product
- PRL-8-53 51352-87-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2023-08-11
- Product
- PRL-8-53 51352-87-5
- Price
- US $10.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%+
- Supply Ability
- 100kgs
- Release date
- 2021-05-19