6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one
- Product Name
- 6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one
- CAS No.
- 4335-12-0
- Chemical Name
- 6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one
- Synonyms
- Toddaculin;Toddaculine;Toddaculin, 10 mM in DMSO;5,7-dimethoxy-6-(3'-methyl-2'-butenyl)coumarin;5,7-Dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one;6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one;5,7-Dimethoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 5,7-dimethoxy-6-(3-methyl-2-buten-1-yl)-;inhibit,Toddaculin,osteoclast,Inhibitor,differentiation,leukemic,Apoptosis,osteoblast,anti-inflammatory,coumarin
- CBNumber
- CB62159892
- Molecular Formula
- C16H18O4
- Formula Weight
- 274.31
- MOL File
- 4335-12-0.mol
6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one Property
- Melting point:
- 95 °C
- Boiling point:
- 432.8±45.0 °C(Predicted)
- Density
- 1.138±0.06 g/cm3(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C16H18O4/c1-10(2)5-6-11-13(18-3)9-14-12(16(11)19-4)7-8-15(17)20-14/h5,7-9H,6H2,1-4H3
- InChIKey
- KRQHZFHWEAJPNO-UHFFFAOYSA-N
- SMILES
- C1(=O)OC2=CC(OC)=C(C/C=C(/C)\C)C(OC)=C2C=C1
- LogP
- 4.151 (est)
N-Bromosuccinimide Price
- Product number
- CFN92733
- Product name
- Toddaculine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $536
- Updated
- 2021/12/16
6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one Chemical Properties,Usage,Production
Uses
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
References
[1] Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. DOI:10.1016/j.phymed.2012.03.008
[2] Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. DOI:10.1371/journal.pone.0127158
[3] Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137. DOI:10.1248/bpb.b17-00607
6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
6-(3-Methyl-2-butenyl)-5,7-dimethoxy-2H-1-benzopyran-2-one Suppliers
- Tel
- 0871-65217109
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 2794
- Advantage
- 58
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- +86-028-82633397 18982077548
- Fax
- +86-28-82633165
- cwb1@biopurify.cn
- Country
- China
- ProdList
- 2376
- Advantage
- 60
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3988
- Advantage
- 66
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 6905
- Advantage
- 55
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8447
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 88915
- Advantage
- 60
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29661
- Advantage
- 68
- Tel
- 028-85370565-229 18080489829
- 18080489829@163.com
- Country
- China
- ProdList
- 7968
- Advantage
- 60
- Tel
- 021-4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52678
- Advantage
- 58