Ambazone hydrate
- Product Name
- Ambazone hydrate
- CAS No.
- 6011-12-7
- Chemical Name
- Ambazone hydrate
- Synonyms
- Iversal;Unii-byk4592A3q;Ambazone hydrate;Ambazone-1-hydrate;Ambazone Monohydrate;1,4-Benzoquinone guanylhydrazone thiosemicarbazone hydrate
- CBNumber
- CB62200358
- Molecular Formula
- C8H13N7OS
- Formula Weight
- 255.30012
- MOL File
- 6011-12-7.mol
Ambazone hydrate Property
- Melting point:
- 188 °C (decomp)(Solv: water (7732-18-5); ammonia (7664-41-7))
Ambazone hydrate Chemical Properties,Usage,Production
Originator
Ambazone,Generic
Uses
Ambazone monohydrate is an orally active membrane active antitumor agent. Ambazone monohydrate also shows antibacterial and weak antiviral activities[1].
Manufacturing Process
To a solution of 22.7 g of quinone monoguanylhydrazone nitrate in 250 ml water is added dropwise hot aqueous solution of 9.1 g thiosemicarbazide, then is added slowly a solution of 5 ml concentrated nitric acid in 10 ml of water. The mixture is stirred at 60°C for 1 hour. The product is dissolved in 1-1.2 L of water at 100°C. The solution is filtered and added to an aqueous ammonium solution. Blue residue of p-benzoquinone amidinohydrazone thiosemicarbazone is filtered and dried, melting point 188°C (decomp.).
Therapeutic Function
Antiseptic
References
[1] G L?ber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. DOI:10.1016/0301-4622(90)80016-z
Ambazone hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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