Ambazone hydrate

Ambazone hydrate Property

Melting point:

188 °C (decomp)(Solv: water (7732-18-5); ammonia (7664-41-7))

Hazard and Precautionary Statements (GHS)

Ambazone hydrate Chemical Properties,Usage,Production

Originator

Ambazone,Generic

Uses

Ambazone monohydrate is an orally active membrane active antitumor agent. Ambazone monohydrate also shows antibacterial and weak antiviral activities[1].

Manufacturing Process

To a solution of 22.7 g of quinone monoguanylhydrazone nitrate in 250 ml water is added dropwise hot aqueous solution of 9.1 g thiosemicarbazide, then is added slowly a solution of 5 ml concentrated nitric acid in 10 ml of water. The mixture is stirred at 60°C for 1 hour. The product is dissolved in 1-1.2 L of water at 100°C. The solution is filtered and added to an aqueous ammonium solution. Blue residue of p-benzoquinone amidinohydrazone thiosemicarbazone is filtered and dried, melting point 188°C (decomp.).

Therapeutic Function

Antiseptic

References

[1] G L?ber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. DOI:10.1016/0301-4622(90)80016-z