(-)-Indolmycin
- Product Name
- (-)-Indolmycin
- CAS No.
- 21200-24-8
- Chemical Name
- (-)-Indolmycin
- Synonyms
- Pa-155-A;indolomycin;(-)-INDOLMYCIN;(S)-5-[(1R)-1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone;[5S,(-)]-5-[(R)-1-(1H-Indol-3-yl)ethyl]-2-methylamino-2-oxazolin-4-one;4(5H)-Oxazolone, 5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-, (5S)-
- CBNumber
- CB62347060
- Molecular Formula
- C14H15N3O2
- Formula Weight
- 257.29
- MOL File
- 21200-24-8.mol
(-)-Indolmycin Property
- Melting point:
- 209-210°
- alpha
- D25 -214° (c = 2 in methanol)
- Boiling point:
- 420.8±37.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light
- solubility
- Soluble in ethanol;methanol;DMSO;dimethyl formamide
- form
- powder
- pka
- 16.65±0.30(Predicted)
- color
- white
N-Bromosuccinimide Price
- Product number
- 15385
- Product name
- Indolmycin
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 15385
- Product name
- Indolmycin
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $1452
- Updated
- 2024/03/01
- Product number
- I708160
- Product name
- Indolmycin
- Packaging
- 1mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- C5289
- Product name
- Indolmycin
- Packaging
- 5mg
- Price
- $1659
- Updated
- 2021/12/16
- Product number
- 0341EM
- Product name
- Indolmycin
- Packaging
- 5mg
- Price
- $1715
- Updated
- 2021/12/16
(-)-Indolmycin Chemical Properties,Usage,Production
Uses
Indolmycin is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that indolmycin is active against Mycobacteria and H. pylori, and can stimulate transcription in Escherichia coli.
Uses
Indolmycin is an antibiotic that inhibits bacterial tryptophanyl-tRNA synthetase.
Definition
ChEBI: A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted at the 2 and 5-pro-S positions by methylamino and [(1R)-1-(1H-indol-3-yl)ethyl] gro ps, respectively.
Biological Activity
indolmycin is an antibiotic.tryptophanyl-trna synthetase (trprs) catalyzes activation of tryptophan through atp and transfer to trnatrp , leading to translation of the genetic code for tryptophan.
in vitro
indolmycin was found to ba a bacteriostatic that showed good activity against methicillin-resistant s. aureus, methicillin-susceptible staphylococcus aureus, and vancomycin-intermediate s. aureus, including strains resistant to mupirocin or fusidic acid. spontaneous indolmycin-resistant mutants was observed at a lower frequency than those selected by mupirocin or fusidic acid and exhibited no cross-resistance with the comparative drugs. high-level resistance of indolmycin at its mic of 128 mg/l that was associated with an h43n mutation in tryptophanyl-trna synthetase, the target enzyme of indolmycin, led to loss of bacterial fitness. however, the locus responsible for low-level indolmycin resistance (indolmycin mics 8-32 mg/l) was not identified [1].
in vivo
animal study found that indolmycin could completely clear h. pylori in experimentally infected mongolian gerbils at a dose of 10 mg/kg. therefore, indolmycin could be regarded as a candidate for the treatment of h. pylori infection [2].
IC 50
30 μm for prokaryotic tryptophanyl-trna synthetase
References
[1] hurdle jg, o'neill aj, chopra i. anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. j antimicrob chemother. 2004 aug;54(2):549-52. epub 2004 jul 8.
[2] vecchione jj, sello jk. a novel tryptophanyl-trna synthetase gene confers high-level resistance to indolmycin. antimicrob agents chemother 2009; 53: 3972-3980.
(-)-Indolmycin Preparation Products And Raw materials
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