VINYL CHLOROFORMATE Property

Boiling point:

68-69 °C735 mm Hg(lit.)

Density 

1.166 g/mL at 20 °C(lit.)

vapor pressure 

0.88 psi ( 20 °C)

refractive index 

n20/D 1.41(lit.)

Flash point:

24 °F

storage temp. 

2-8°C

form 

Liquid

color 

Clear colorless

BRN 

1741679

Safety

Hazard Codes 

F,T

Risk Statements 

23/24/25-34-11

Safety Statements 

16-26-36-45-36/37

RIDADR 

UN 3390 6.1/PG 1

WGK Germany 

3

F 

10-21-19

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29159000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

VINYL CHLOROFORMATE Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

Vinyl Chloroformate was used to prepare analogues of the Nicotinic Acetylcholine Receptor Agonist (±)-UB-165. It was also used to synthesize possible antitumor agents such as paclitaxel-2''-carbonates and N-carbamyl triazenes.

Purification Methods

It has been fractionated through a Todd column (p 11, Model A with ~60 plates) under atmospheric pressure and the purity can be checked by gas chromatography. Stabilize it with 0.5% of 2,6-di-tert-butyl-p-cresol. It has IR with at 3100 + 2870 (CH2), 1780 (C=O), 1640 (C=C) and 940 (CH2out-of-plane) and 910 (CH2 wagging) cm-1. [IR: Lee J Org Chem 30 3943 1965, Levaillant Ann Chim (Paris) 6 504 1936.] It is used for protecting NH2 groups in peptide synthesis [Olofson et al. Tetrahedron Lett 1563 1977]. [Beilstein 3 III 28.]