BW A868C

Product Name: BW A868C
CAS No.: 118675-50-6
Chemical Name: BW A868C
Synonyms: BW A868C;(+/-)-3-BENZYL-5-(6-CARBOXYHEXYL)-1-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)HYDANTOIN;3-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)-2,5-DIOXO-1-BENZYL-4-IMIDAZOLIDINEHEPTANOIC ACID;4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-;3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid;7-[3-[(2-CYCLOHEXYL-2-HYDROXYETHYL)AMINO]-2,5-DIOXO-1-(PHENYLMETHYL)-4-IMIDAZOLIDINYL]HEPTANOIC ACID
CBNumber: CB6236339
Molecular Formula: C25H37N3O5
Formula Weight: 459.58
MOL File: 118675-50-6.mol

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BW A868C Property

Boiling point:: 638.1±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: >5 mg/mL, soluble
form: solid
pka: 4.77±0.10(Predicted)
color: colorless

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B9180
Product name: BW A868C
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $774
Updated: 2024/03/01

Cayman Chemical

Product number: 12060
Product name: BW A868C
Purity: ≥98%
Packaging: 1mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 12060
Product name: BW A868C
Purity: ≥98%
Packaging: 5mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 12060
Product name: BW A868C
Purity: ≥98%
Packaging: 10mg
Price: $680
Updated: 2024/03/01

TRC

Product number: B820028
Product name: BW A868C
Packaging: 1mg
Price: $125
Updated: 2021/12/16

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BW A868C Chemical Properties,Usage,Production

Uses

BW A868C is a hydantoin compound structurally related to the DP agonist BW245C.

Definition

ChEBI: BW A868C is an imidazolidine-2,4-dione.

Biological Activity

bw a868c is a novel, selective and potent competitive antagonist of prostaglandin d2 (pgd2) [1].prostaglandin d2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system [2]. prostaglandin d2 is critical for the development of allergic diseases such as asthma.

in vitro

in glycerol-lysed human platelets, bw245c activated adenylate cyclase in a biphasic manner. bw a868c showed no effect on carbacyclin, iloprost, prostacyclin, pge1 and pge2 at a concentration 1,000 fold that of its kb against pgd2 and bw245c [1]. bw a868c showed no effect on human tp, ip, ep1, ep2, and fp receptors. the ki value for bw a868c is approximately 1.7 nm[1] .in isolated rings of rabbit saphenous vein (rbsv) pre-contracted with 40 mm kcl, bw245c caused concentration-dependent relaxations with an ec50 of 38 nm [3].

References

[1] giles h, leff p, bolofo m l, et al. the classification of prostaglandin dp‐receptors in platelets and vasculature using bw a868c, a novel, selective and potent competitive antagonist[j]. british journal of pharmacology, 1989, 96(2): 291-300.
[2] shimizu t, mizuno n, amano t, et al. prostaglandin d2, a neuromodulator[j]. proceedings of the national academy of sciences, 1979, 76(12): 6231-6234.
[3] lydford s j, mckechnie k c w, leff p. interaction of bw a868c, a prostanoid dp-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein[j]. prostaglandins, 1996, 52(2): 125-139.

BW A868C Preparation Products And Raw materials

Raw materials

Preparation Products

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BW A868C Suppliers

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118675-50-6, BW A868CRelated Search:

BW A868C 1-Aminohydantoin hydrochloride SALOR-INT L173312-1EA Octamoxin

BW A868C

3-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)-2,5-DIOXO-1-BENZYL-4-IMIDAZOLIDINEHEPTANOIC ACID

(+/-)-3-BENZYL-5-(6-CARBOXYHEXYL)-1-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)HYDANTOIN

7-[3-[(2-CYCLOHEXYL-2-HYDROXYETHYL)AMINO]-2,5-DIOXO-1-(PHENYLMETHYL)-4-IMIDAZOLIDINYL]HEPTANOIC ACID

3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid

4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-

118675-50-6

C25H37N3O5