5-Methylthiophene-2-carboxaldehyde

Product Name: 5-Methylthiophene-2-carboxaldehyde
CAS No.: 13679-70-4
Chemical Name: 5-Methylthiophene-2-carboxaldehyde
Synonyms: 5-METHYL-2-THIOPHENECARBOXALDEHYDE;5-METHYLTHIOPHENE-2-CARBALDEHYDE;2-Formyl-5-methylthiophene;FEMA 3209;AKOS B015983;bread thiophene;AKOS BBS-00003245;TIMTEC-BB SBB004249;LABOTEST-BB LT00936047;5-Methyl-2-thenaldehyde
CBNumber: CB6243962
Molecular Formula: C6H6OS
Formula Weight: 126.18
MOL File: 13679-70-4.mol

More

Less

5-Methylthiophene-2-carboxaldehyde Property

Melting point:: 184-186 °C
Boiling point:: 114 °C/25 mmHg (lit.)
Density: 1.17 g/mL at 25 °C (lit.)
refractive index: n20/D 1.583(lit.)
FEMA: 3209 | 5-METHYL-2-THIOPHENECARBOXALDEHYDE
Flash point:: 190 °F
storage temp.: 2-8°C
solubility: Soluble in ether and ethanol.
form: Liquid
Specific Gravity: 1.180
color: Clear yellow to brown
Odor: at 0.10 % in dipropylene glycol. sweet almond cherry furfural woody acetophenone
Odor Type: fruity
biological source: synthetic
Sensitive: Air Sensitive
JECFA Number: 1050
BRN: 106896
InChIKey: VAUMDUIUEPIGHM-UHFFFAOYSA-N
LogP: 1.48
CAS DataBase Reference: 13679-70-4(CAS DataBase Reference)
NIST Chemistry Reference: 5-Methyl-2-thiophenecarboxaldehyde(13679-70-4)
EPA Substance Registry System: 2-Thiophenecarboxaldehyde, 5-methyl- (13679-70-4)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-24/25-36-26-7/9-37
WGK Germany: 3
F: 8
Hazard Note: Irritant
TSCA: T
HazardClass: IRRITANT, AIR SENSITIVE
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H227Combustible liquid
Precautionary statements: P403+P235Store in a well-ventilated place. Keep cool.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W320900
Product name: 5-Methyl-2-thiophenecarboxaldehyde
Purity: FG
Packaging: 1 unit
Price: $56.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: W320900
Product name: 5-Methyl-2-thiophenecarboxaldehyde
Purity: FG
Packaging: 1 unit
Price: $56.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: W320900
Product name: 5-Methyl-2-thiophenecarboxaldehyde
Purity: FG
Packaging: 100g
Price: $278
Updated: 2025/07/31

Sigma-Aldrich

Product number: W320900
Product name: 5-Methyl-2-thiophenecarboxaldehyde
Purity: FG
Packaging: 1kg
Price: $1850
Updated: 2025/07/31

Sigma-Aldrich

Product number: M84410
Product name: 5-Methyl-2-thiophenecarboxaldehyde
Purity: 98%
Packaging: 25g
Price: $50.4
Updated: 2025/07/31

More

Less

5-Methylthiophene-2-carboxaldehyde Chemical Properties,Usage,Production

Description

May be synthesized from thiophene (or its derivatives) and formamide in the presence of POCl3; from N-(2-thenyl)formaldimines.

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Occurrence

Reported found in French fried potato, roasted peanuts, tomato, wheat bread, raw chicken, cooked beef, pork liver, cognac, malt whiskey, coffee, popcorn, krill, shrimp and okra

Uses

5-Methylthiophene-2-carboxaldehyde is used as a food additive. It is an analytical reagent. The reagent has been synthesized and characterized using IR, 1H NMR and Mass spectral data.

Definition

ChEBI: 5-Methyl-2-thiophenecarboxaldehyde is a member of thiophenes.

Preparation

From thiophene (or its derivatives) and formamide in the presence of POCl3; from N-(2-thienyl)formaldimines.

Taste threshold values

Taste characteristics at 5 ppm: sweet, almond, fruity, heliotropine and nutty

General Description

5-Methyl-2-thiophenecarboxaldehyde can be obtained as a product from 2-thiophenecarboxaldehyde via metalation, and alkylation, followed by a series of reactions.

Synthesis

554-14-3

68-12-2

13679-70-4

GENERAL STEPS: A tetrahydrofuran (THF) solution of 0.99 M ethylmagnesium chloride (EtMgCl, 0.61 mL, 0.6 mmol) was cooled to 0°C under nitrogen protection, and dicyclohexylamine (0.01 mL, 0.05 mmol) and 2-methylthiophene (1a, 0.048 mL, 0.50 mmol) were slowly added dropwise. The reaction mixture was warmed to 60°C and stirred for 24 hours. Subsequently, 1.4 mL of THF and N,N-dimethylformamide (DMF, 0.5 mL, 6.46 mmol) were added sequentially and stirring was continued at 60°C for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (1.0 mL) and the mixture was poured into a solvent mixture of ether/water to separate the organic and aqueous phases. The aqueous phase was extracted twice with ether, the organic layers were combined and dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to obtain the crude product, which was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=20/1) to give 5-methyl-2-thiophenecarboxaldehyde (1a-CHO, 62.3 mg, colorless oil, 99% yield).

References

[1] Tetrahedron Letters, 2012, vol. 53, # 9, p. 1173 - 1176
[2] Dyes and Pigments, 2014, vol. 106, p. 154 - 160
[3] Patent: EP1555257, 2005, A1. Location in patent: Page/Page column 25-26
[4] Pharmaceutical Chemistry Journal, 1989, vol. 23, # 7, p. 592 - 596
[5] Khimiko-Farmatsevticheskii Zhurnal, 1989, vol. 23, # 7, p. 840 - 843

5-Methylthiophene-2-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

5-METHYLTHIOPHEN-2-YLMETHYLAMINE

More

Less

5-Methylthiophene-2-carboxaldehyde Suppliers

Americas 2 Belgium 2 Canada 1 China 212 Europe 1 France 1 Germany 7 India 13 Japan 3 Switzerland 2 Ukraine 2 United Kingdom 13 United States 56 USA 1 Global 316

Wuhan zhijingcheng Pharmaceutical Technology Co.，Ltd

Tel: 13871097899
Fax: 13986215120
Email: chemistry888@126.com
Country: China
ProdList: 45
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

More

Less

View Lastest Price from 5-Methylthiophene-2-carboxaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Methylthiophene-2-carboxaldehyde 13679-70-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Hebei Yanxi Chemical Co., Ltd.

Product: 5-Methylthiophene-2-carboxaldehyde 13679-70-4
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-13

JINING XINHE CHEMICAL CO., LTD

Product: 5-Methylthiophene-2-carboxaldehyde 13679-70-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10ton
Release date: 2024-07-18

13679-70-4, 5-Methylthiophene-2-carboxaldehydeRelated Search:

5-Methyl-2-thiophenecarboxylic acid 5-METHYL-2-NITROANILINE 5-METHYL-2-THIOPHENESULFONYL CHLORIDE 5-Methylthiophene-2-carboxaldehyde 2-ACETYL-3-AMINO-5-PHENYLTHIOPHENE 1-(5-Methyl-2-thienyl)ethan-1-one 2,5-Thiophenedicarboxylic acid 2-[1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL]-THIOPHENE-5-CARBOXALDEHYDE 2,2'-BITHIOPHENE-5-CARBOXALDEHYDE 5-Acetylthiophene-2-carboxylic acid 5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID Methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 2-ACETYL-5-CYANOTHIOPHENE 2-Methyl-5-propionylthiophene 3-Methyl-2-thiophenecarboxaldehyde 5-(1,3,2-dioxaborinan-2-yl)-3-methylthiophene-2-carboxaldehyde Formaldehyde 2-Thiophenecarboxaldehyde

5-Methyl-2-thiophenecarboxaldehyde, 98% 10ML

5-Methylthiophene-2-aldehyde 2-Formyl-5-methylthiophene

5-methyl-2-thiopene carboxaldehyde

5-METHYL-2-THIOPHENECARBOXALDEHYDE 98+%

5-METHYLTHIOPHENE-2-CARBOXALDEHYDE, STAB .

5-METHLY-2-THIOPHENECARBOXALDEHYDE

formylmethylthiophene,2-formyl-5-methylthiophene

5-Methylthiophene-2-carboxaldehyde 97%

5-METHYL-2-THIOPHENECARBOXLDEHYDE

2-FORMYL-5-METHYLTHIOPHEN

2-Methyl-5-thiophenecarboxaldehyde

5-METHYLTHIOPHENE-2-CARBOXALDEHYDE, 98+%

2-Methyl-5-formylthiophene

5-Methyl-2-thienaldehyde

5-Methylthiophene-2-carboxaldeyde

5-Methyl-2-thenaldehyde

5-Methylthiophene-2-aldehyde (=5-Methyl-2-thiophenecarboxaldehyde)

2-Formyl-5-methylthiophene, 5-Methyl-2-thenaldehyde

5-Methyl-2-thiophenecarboxaldehyde, 97+%

5 - Methyl - 2 - thiophene forMaldehyde

5-Methylthiophene-2-carbaldehyde for synthesis

2-Formyl-5-methylthiophene

2-Thiophenecarboxaldehyde, 5-methyl-

5-Methyl-2-formylthiophene

5-Methyl-2-thiophencarboxaldehyde

5-methyl-2-thiophenecarboxaldehyd

Thiophen-2-carboxaldehyde, 5-methyl

thiophene, 2-Methyl, 5-formyl

5-METHYL-THIOPHEN-2-ALDEHYDE

5-METHYLTHIOPHENE-2-CARBOXALDEHYDE

5-METHYLTHIOPHENE-2-ALDEHYDE

5-METHYLTHIOPHENE-2-CARBALDEHYDE

5-METHYL-2-THIOPHENECARBALDEHYDE

5-METHYL-2-THIOPHENECARBOXALDEHYDE

AKOS BBS-00003245

AKOS B015983

LABOTEST-BB LT00936047

FEMA 3209

TIMTEC-BB SBB004249

5-Methylthiophene-2-carboxaldehyde&gt

5-Methylthiophene-2-carboxaldehyde ISO 9001：2015 REACH

bread thiophene

13679-70-4 5-Methylthiophene-2-carboxaldehyde

5-Methyl-2-thiophenecarboxaldehyde, 10 mM in DMSO

13679-70-4

13679-701-4

C6H5OS

ALDEHYDE

Building Blocks

Heterocyclic Building Blocks

Thiophenes

Building Blocks

C1 to C6

C4 to C6

Carbonyl Compounds

Chemical Synthesis

Heterocyclic Building Blocks

Organic Building Blocks