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GlyH-101

Product Name
GlyH-101
CAS No.
328541-79-3
Chemical Name
GlyH-101
Synonyms
LYH101;CS-1049;GLYH-101;CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101;CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem;Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II;GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-NAPHTHALENYL-2-[(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]GLYCINE HYDRAZIDE
CBNumber
CB62446668
Molecular Formula
C19H15Br2N3O3
Formula Weight
493.15
MOL File
328541-79-3.mol
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GlyH-101 Property

Melting point:
>300℃ (ethanol )
Density 
1.73±0.1 g/cm3(Predicted)
storage temp. 
= -70C
solubility 
DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM)
DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM)
form 
Yellow solid
pka
5.44±0.45(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219675
Product name
InSolutionCFTRInhibitorII,GlyH-101-CAS328541-79-3-Calbiochem
Packaging
5mg
Price
$230
Updated
2024/03/01
Sigma-Aldrich
Product number
219671
Product name
CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem<br />CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 μM in CFTR-expressing FRT cells).
Packaging
5mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
15772
Product name
CFTR Inhibitor II
Purity
≥95%
Packaging
5mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
15772
Product name
CFTR Inhibitor II
Purity
≥95%
Packaging
25mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
15772
Product name
CFTR Inhibitor II
Purity
≥95%
Packaging
50mg
Price
$263
Updated
2024/03/01
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GlyH-101 Chemical Properties,Usage,Production

Description

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 μM). This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport. Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin. It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.

Uses

N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.

Definition

ChEBI: Glycine, n-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a member of naphthalenes.

General Description

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

GlyH-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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GlyH-101 Suppliers

Canada 1 China 61 India 1 United Kingdom 2 United States 17 Global 82
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from GlyH-101 manufacturers

Career Henan Chemical Co
Product
(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE 328541-79-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

328541-79-3, GlyH-101Related Search:

GlyH-101

  • (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
  • GLYH-101
  • Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide
  • N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
  • N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
  • GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
  • N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II
  • CFTR Inhibitor II, GlyH-101
  • N'-[(3,5-DIBROMO-4-HYDROXY-6-OXOCYCLOHEXA-2,4-DIEN-1-YLIDENE)METHYL]-2-(NAPHTHALEN-2-YLAMINO)ACETOHYDRAZIDE
  • N-2-NAPHTHALENYL-2-[(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]GLYCINE HYDRAZIDE
  • CFTR Inhibitor II
  • CS-1049
  • Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II
  • GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II
  • CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem
  • GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II;GLYH 101;GLYH101
  • Glycine, N-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
  • Inhibitor,antiproliferative,PCT,inhibit,PS120 cells,GlyH101,intestinal fluid,GlyH-101,VSORC,CFTR-like current,Cystic fibrosis transmembrane conductance regulator,CFTR
  • N'-(3,5-Dibromo-2,4-dihydroxybenzylidene)-2-(naphthalen-2-ylamino)acetohydrazide
  • N'-(3,5-Dibromo-2,4-dihydroxybenzylidene)-2-(naphthalen-2-ylamino)acetohydrazide
  • LYH101
  • 328541-79-3
  • C19H15Br2N3O3
  • Inhibitors
  • CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound.