ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE
- Product Name
- ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE
- CAS No.
- 119647-69-7
- Chemical Name
- ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE
- Synonyms
- ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE;1H-Pyrrole-2-carboxylic acid, 4-acetyl-, ethyl ester
- CBNumber
- CB62449407
- Molecular Formula
- C9H11NO3
- Formula Weight
- 181.19
- MOL File
- 119647-69-7.mol
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE Property
- storage temp.
- Store at room temperature
- Appearance
- Light brown to pink Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A144406
- Product name
- Ethyl4-acetyl-1H-pyrrole-2-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $12
- Updated
- 2021/12/16
- Product number
- 119647697
- Product name
- Ethyl4-acetyl-1H-pyrrole-2-carboxylate
- Packaging
- 250mg
- Price
- $190.08
- Updated
- 2021/12/16
- Product number
- CM248110
- Product name
- Ethyl4-acetyl-1H-pyrrole-2-carboxylate
- Purity
- 95%+
- Packaging
- 1g
- Price
- $449
- Updated
- 2021/12/16
- Product number
- CD11334222
- Product name
- Ethyl4-acetyl-1H-pyrrole-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- 119647697
- Product name
- Ethyl4-acetyl-1H-pyrrole-2-carboxylate
- Packaging
- 1g
- Price
- $504
- Updated
- 2021/12/16
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
2199-43-1
75-36-5
119647-69-7
In a two-necked round-bottomed flask equipped with an argon inlet, 4.0 g (28.8 mmol) of ethyl pyrrole-2-carboxylate was dissolved in 100 mL of 1,2-dichloroethane. Subsequently, 8.0 g of anhydrous aluminum trichloride was slowly added. Next, 4.4 mL (62 mmol) of acetyl chloride dissolved in 50 mL of 1,2-dichloroethane was added dropwise over 15 minutes. The reaction mixture was stirred at room temperature for 1 hour and then carefully poured into 200 g of crushed ice for hydrolysis. The mixture was transferred to a separatory funnel and the organic phase was separated. The aqueous phase was extracted with dichloromethane (2 × 200 mL) and the combined organic phases were washed sequentially with saturated aqueous sodium bicarbonate (1 × 100 mL) and deionized water (1 × 100 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. Purification by silica gel column chromatography (eluent: dichloromethane solution containing 1% methanol) afforded 4.0 g (76% yield) of the target product ethyl 4-acetyl-1H-pyrrole-2-carboxylate as a light brown powder.
References
[1] Heterocycles, 1988, vol. 27, # 8, p. 1855 - 1860
[2] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 1, p. 48 - 54
[3] Patent: US2003/229131, 2003, A1. Location in patent: Page 24
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE Suppliers
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