CATESTATIN

CATESTATIN Property

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble to 2 mg/ml in 10% acetonitrile

form 

Powder

color 

White to off-white

Sequence

Arg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Leu-Gln-Leu

InChIKey

HCEYIDADOJWYIM-DIWOTYQXSA-N

Hazard and Precautionary Statements (GHS)

CATESTATIN Chemical Properties,Usage,Production

Description

Catestatin is a small molecule active peptide obtained by enzymatic hydrolysis of casein as raw material. It has the functions of lowering blood pressure, lowering blood sugar, antithrombotic and improving sleep. Casein accounts for about 80% of the total protein content of cow milk, and is one of the important sources of high-quality protein in people's daily life. Catestatin contains many amino acids necessary for human growth and is also a good source of bioactive peptides.

Uses

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure[1]. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release[2].

Health effects

Catestatin can inhibit angiotensin-converting enzyme (ACE). It can inhibit the activity of angiotensin-converting enzyme (ACE), reduce the production of angiotensin II and the inactivation of bradykinin, so as to achieve the purpose of lowering blood pressure without affecting normal blood pressure, and is suitable for long-term use. It can be seen that Catestatin is a safe, natural and efficient anti-hypertensive health food raw material.

Biological Activity

Catestatin is a 21 amino acid residue, cationic, hydrophobic peptide. It is an endogenous peptide that regulates cardiac function and blood pressure, and it is a noncompetitive nicotinic antagonist that inhibits catecholamine release through nicotinic acetylcholine receptors (nAChRs).

References

[1] Nitish R Mahapatra. Catestatin Is a Novel Endogenous Peptide That Regulates Cardiac Function and Blood Pressure. Cardiovasc Res. 2008 Dec 1;80(3):330-8. DOI:10.1093/cvr/cvn155
[2] Sebastian Kraszewski, et al. A Molecular Dynamics Study of Catestatin Docked on Nicotinic Acetylcholine Receptors to Identify Amino Acids Potentially Involved in the Binding of Chromogranin A Fragments. Phys Chem Chem Phys. 2015 Jul 14;17(26):17454-60. DOI:10.1039/c4cp02491e