4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE
- Product Name
- 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE
- CAS No.
- 898044-50-3
- Chemical Name
- 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE
- Synonyms
- 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE;Pyrimidine, 4-chloro-5-fluoro-2-methyl-;4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB62451075
- Molecular Formula
- C5H4ClFN2
- Formula Weight
- 146.55
- MOL File
- 898044-50-3.mol
4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE Property
- Boiling point:
- 176.9±20.0 °C(Predicted)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -0.65±0.29(Predicted)
- Appearance
- Colorless to light yellow Solid-Liquid Mixture
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C585045
- Product name
- 4-Chloro-5-fluoro-2-methylpyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C585045
- Product name
- 4-Chloro-5-fluoro-2-methylpyrimidine
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C585045
- Product name
- 4-Chloro-5-fluoro-2-methylpyrimidine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3H32-7-1S
- Product name
- 4-Chloro-5-fluoro-2-methylpyrimidine
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 074518
- Product name
- 4-Chloro-5-fluoro-2-methylpyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE Chemical Properties,Usage,Production
Uses
4-Chloro-5-fluoro-2-methylpyrimidine
Synthesis
1480-91-7
898044-50-3
General procedure for the synthesis of 4-chloro-5-fluoro-2-methylpyrimidine from 5-fluoro-2-methylpyrimidin-4(3H)-one: 5-fluoro-2-methylpyrimidin-4(3H)-one (1.04 g, 7.21 mmol) and N,N-dimethylaniline (1.80 mL) were dissolved in phosphorus trichloride and heated to a reaction temperature of 110 °C for 90 min. After the reaction was completed, it was cooled to room temperature and the reaction mixture was carefully poured into ice water. The product was extracted with diethyl ether, and the ether layer was washed sequentially with 2N hydrochloric acid, water and saturated saline, and then dried with anhydrous magnesium sulfate. The ether was removed by careful evaporation under reduced pressure to give the volatile liquid product 4-chloro-5-fluoro-2-methylpyrimidine (0.39 g, 34% yield), which could be used in subsequent reactions without further purification. Thin layer chromatography (TLC) Rf value was 0.26 (unfolding agent: 10% ethyl acetate/hexane).1H NMR (400 MHz, DMSO-d6): δ 3.91 (s, 3H), 8.79 (s, 1H).
References
[1] Patent: WO2008/96260, 2008, A1. Location in patent: Page/Page column 40
4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE Suppliers
- Tel
- --
- Fax
- --
- info@borochem.fr
- Country
- France
- ProdList
- 852
- Advantage
- 46
View Lastest Price from 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE manufacturers
- Product
- 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE 898044-50-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 4-CHLORO-5-FLUORO-2-METHYL-PYRIMIDINE 898044-50-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-98%
- Supply Ability
- 200KG
- Release date
- 2019-09-03