ChemicalBook > CAS DataBase List > 4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID

4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID

Product Name
4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID
CAS No.
130332-27-3
Chemical Name
4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID
Synonyms
[R-(R*,R*)]-4-[[2-[[3-(1H-Indol-3-yl)-2-Methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-;4-(((R)-2-((R)-2-(((Adamantan-2-yloxy)carbonyl)amino)-3-(1H-indol-3-yl)-2-methylpropanamido)-1-phenylethyl)amino)-4-oxobutanoic acid;4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID;Butanoic acid, 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxo-
CBNumber
CB62453428
Molecular Formula
C35H42N4O6
Formula Weight
614.73
MOL File
130332-27-3.mol
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4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID Property

storage temp. 
Store at +4°C
solubility 
Soluble to 100 mM in DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C432695
Product name
CI-988
Packaging
100mg
Price
$1540
Updated
2021/12/16
TRC
Product number
C432695
Product name
CI-988
Packaging
250mg
Price
$3025
Updated
2021/12/16
ApexBio Technology
Product number
B7126
Product name
CI988
Packaging
10mg
Price
$465
Updated
2021/12/16
ApexBio Technology
Product number
B7126
Product name
CI988
Packaging
50mg
Price
$1841
Updated
2021/12/16
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4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID Chemical Properties,Usage,Production

Uses

CI-988 is a potent and selective cholecystokinin 2 (CCK-2) receptor antagonist that displays ~ 1600-fold selectivity over CCK1 receptors and has negligible affinity at other binding sites. CI-988 exhibits anxiolytic activity following oral administration. CI-98 inhibited the proliferation of small cell lung cancer (SCLC) cells in mice.

Biological Activity

Potent and selective CCK 2 (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK 1 receptors (IC 50 values are 1.7 and 2717 nM for CCK 2 and CCK 1 respectively). Has negligible affinity at a range of other binding sites (IC 50 > 10 μ M). Exhibits anxiolytic activity following oral administration.

storage

Store at +4°C

4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID Suppliers

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130332-27-3, 4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACIDRelated Search:

Procymate 4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID

  • [R-(R*,R*)]-4-[[2-[[3-(1H-Indol-3-yl)-2-Methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-
  • 4-[[(1R)-2-[[(2R)-3-(1H-INDOL-3-YL)-2-METHYL-1-OXO-2-[[(TRICYCLO[3.3.1.13,7]DEC-2-YLOXY)CARBONYL]AMINO]PROPYL]AMINO]-1-PHENYLETHYL]AMINO]-4-OXOBUTANOIC ACID
  • Butanoic acid, 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxo-
  • 4-(((R)-2-((R)-2-(((Adamantan-2-yloxy)carbonyl)amino)-3-(1H-indol-3-yl)-2-methylpropanamido)-1-phenylethyl)amino)-4-oxobutanoic acid
  • 130332-27-3
  • Aromatics
  • Heterocycles
  • Indole Derivatives
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals