4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL

ChemicalBook > CAS DataBase List > 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL

Product Name: 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
CAS No.: 805239-56-9
Chemical Name: 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL
Synonyms: PHTPP;4-[2-phenyl-5;PHTPP, 10 mM in DMSO;PHTPP, ERbeta antagonist;5-a]pyrimidin-3-yl]phenol;7-bis(trifluoromethyl)pyrazolo[1;4-[2-PHENYL-5，7-BIS(TRIFLUOROMETHYL)PYRA...;Inhibitor,inhibit,Estrogen Receptor/ERR,PHTPP;4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL;Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
CBNumber: CB62453433
Molecular Formula: C20H11F6N3O
Formula Weight: 423.31
MOL File: 805239-56-9.mol

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4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Property

storage temp.: 2-8°C
solubility: DMSO : 25 mg/mL (59.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: powder
color: yellow to orange

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1355
Product name: PHTPP
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $129
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1355
Product name: PHTPP
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $507
Updated: 2023/06/20

Cayman Chemical

Product number: 16025
Product name: PHTPP
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 16025
Product name: PHTPP
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 16025
Product name: PHTPP
Purity: ≥98%
Packaging: 25mg
Price: $433
Updated: 2024/03/01

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4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Chemical Properties,Usage,Production

Description

PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα. It exhibits no significant agonism on ERα or ERβ. This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype. At 100 pM, PHTPP has been found to enhance SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.

Uses

PHTPP can be used in pharmaceutical combination chemotherapy for treatment of cancer by exploiting estrogen receptor β (ERβ) and TP53 interaction.

Definition

ChEBI: 4-[2-phenyl-5,7-bis(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]phenol is a member of pyrazoles and a ring assembly.

Biological Activity

Selective estrogen ER β receptor antagonist that displays 36-fold selectivity over ER α . Exhibits full antagonism at ER β in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ER α .

Biochem/physiol Actions

PHTPP is a selective estrogen receptor β (ERβ) full antagonist with 36-fold selectivity for ERβ over ERα. PHTPP has been used to distinguish the various activites of the two estrogen receptors. Estrogen can have opposite effects in some tumors expressing ERα compared to Erβ, with Erα enhancing and Erβ suppressing tumor cell growth. PHTPP, a selective ERβ antagonist, significantly enhanced cell growth in ovarian cancer cell lines SKOV3 and OV2008 that express both receptors.

storage

Room temperature

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL Suppliers

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805239-56-9, 4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOLRelated Search:

4-[2-PHENYL-5,7-BIS(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]PHENOL

PHTPP

4-[2-phenyl-5

5-a]pyrimidin-3-yl]phenol

7-bis(trifluoromethyl)pyrazolo[1

Phenol, 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-

4-[2-PHENYL-5，7-BIS(TRIFLUOROMETHYL)PYRA...

Inhibitor,inhibit,Estrogen Receptor/ERR,PHTPP

PHTPP, ERbeta antagonist

PHTPP, 10 mM in DMSO

805239-56-9

C20H11F6N3O