3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE
- Product Name
- 3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE
- CAS No.
- 215878-20-9
- Chemical Name
- 3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE
- Synonyms
- 3-(4-Piperidinyl);-1,3-benzoxazol-2(3H);3-(4-piperidinyl)-2(3H)-Benzoxazolone;2(3H)-Benzoxazolone, 3-(4-piperidinyl)-;3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE;3-(piperidin-4-yl)benzo[d]oxazol-2(3H)-one
- CBNumber
- CB62453716
- Molecular Formula
- C12H14N2O2
- Formula Weight
- 218.25
- MOL File
- 215878-20-9.mol
3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P475538
- Product name
- 3-(4-Piperidinyl)-1,3-benzoxazol-2(3H)-one
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W4481
- Product name
- 3-(4-Piperidinyl)-1,3-benzoxazol-2(3H)-one
- Packaging
- 1g
- Price
- $264
- Updated
- 2021/12/16
- Product number
- 072409
- Product name
- 3-(4-Piperidinyl)-1,3-benzoxazol-2(3H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $324
- Updated
- 2021/12/16
- Product number
- CHM0167350
- Product name
- 3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $933.24
- Updated
- 2021/12/16
- Product number
- CHM0167350
- Product name
- 3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1346.73
- Updated
- 2021/12/16
3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE Chemical Properties,Usage,Production
Synthesis
162045-53-6
215878-20-9
D. Synthesis of 3-piperidin-4-yl-3H-benzoxazol-2-one. To a stirred solution of 1.00 g (2.87 mmol) of tert-butyl 4-(2-oxobenzo[D]oxazol-3(2H)-yl)piperidine-1-carboxylate in dichloromethane (6.0 mL) was added trifluoroacetic acid (6.0 mL) and the mixture was stirred for 12 hours. After the reaction was complete, the solvent was removed under reduced pressure, the crude product was diluted with methanol (10 mL), saturated sodium bicarbonate solution (15 mL) was added to the mixture and stirring was continued for 10 minutes. The reaction mixture was diluted with dichloromethane (30 mL) and the organic and aqueous layers were separated. The aqueous phase was extracted with dichloromethane (2 x 20 mL), all organic layers were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent, yielding 1.02 g (88% yield) of light yellow solid product. Thin-layer chromatography (silica gel, 10% methanol/dichloromethane): Rf = 0.1. Mass spectrometry (electrospray): m/z calculated value C12H14N2O2, [M + H]+, 219.11, measured value 219.1.
References
[1] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 18, p. 2467 - 2472
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 12, p. 3421 - 3425
[3] Patent: US2005/101587, 2005, A9
3-(4-PIPERIDINYL)-1,3-BENZOXAZOL-2(3H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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