2-CHLORO-3-NITROPYRAZINE
- Product Name
- 2-CHLORO-3-NITROPYRAZINE
- CAS No.
- 87885-43-6
- Chemical Name
- 2-CHLORO-3-NITROPYRAZINE
- Synonyms
- 3-Chloro-2-nitropyrazine;2-CHLORO-3-NITROPYRAZINE;Pyrazine, 2-chloro-3-nitro-
- CBNumber
- CB62454586
- Molecular Formula
- C4H2ClN3O2
- Formula Weight
- 159.53
- MOL File
- 87885-43-6.mol
2-CHLORO-3-NITROPYRAZINE Property
- Boiling point:
- 283℃
- Density
- 1.600
- Flash point:
- 125℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -5.91±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C370995
- Product name
- 3-Chloro-2-nitropyrazine
- Packaging
- 1g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- Y5600
- Product name
- 2-Chloro-3-nitropyrazine
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FC46678
- Product name
- 3-Chloro-2-nitropyrazine
- Packaging
- 100mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- HCH0364764
- Product name
- 3-CHLORO-2-NITROPYRAZINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $391.65
- Updated
- 2021/12/16
- Product number
- FC46678
- Product name
- 3-Chloro-2-nitropyrazine
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
2-CHLORO-3-NITROPYRAZINE Chemical Properties,Usage,Production
Uses
3-Chloro-2-nitropyrazine is a building block to prepare substituted benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists. It is also used to prepare hypoxic cell radiosensitizers.
Synthesis
86536-74-5
87885-43-6
The general procedure for the synthesis of 2-chloro-3-nitropyrazine from the compound (CAS:86536-74-5) was as follows: m-chloroperbenzoic acid (8.0 g, 0.46 mmol, 85%) was dissolved in dichloromethane (100 mL) and cooled to -5 °C. At this temperature, a dichloromethane solution of S,S-dimethyl-N-(2-pyrazinyl)thiimine (5.36 g, 0.028 mmol, dissolved in 30 mL of dichloromethane) was slowly added, and the rate of addition was controlled so that the reaction temperature did not exceed 0 °C, and the addition process lasted for 1 hour. After the addition was completed, the reaction mixture was continued to be stirred at 0 °C for 40 min. Subsequently, a dichloromethane solution of dimethyl sulfide was added at 0 °C and quickly processed to obtain an orange colored clarified solution. The solution was cooled to -78°C and then ozone was passed until the orange solution became colorless. Upon completion of the reaction, the reaction was quenched with sodium dicarbonate solution and then extracted three times with dichloromethane. The organic phases were combined and concentrated to give the crude product. The crude product was purified by fast chromatography to afford 2-chloro-3-nitropyrazine (0.5 g, yield: 7%).1H NMR (DMSO-d6) data were consistent with the structure of the target product.
References
[1] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 4, p. 947 - 950
[2] Patent: US2006/47126, 2006, A1. Location in patent: Page/Page column 25
[3] Patent: WO2011/5759, 2011, A2. Location in patent: Page/Page column 69
[4] Patent: WO2013/78254, 2013, A1. Location in patent: Paragraph 00349
2-CHLORO-3-NITROPYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-NITROPYRAZINE manufacturers
- Product
- 5-NITRO-PYRIDIN-3-YLAMINE 87885-43-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2020-01-07
- Product
- DIPHENYL-N-PROPYLPHOSPHINE 7650-84-2
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2020-01-07