8-CHLOROQUINAZOLIN-4(1H)-ONE
- Product Name
- 8-CHLOROQUINAZOLIN-4(1H)-ONE
- CAS No.
- 101494-95-5
- Chemical Name
- 8-CHLOROQUINAZOLIN-4(1H)-ONE
- Synonyms
- 8-chloroquinazolin-4-ol;8-chloroquinazolin-4(3H)-one;8-CHLOROQUINAZOLIN-4(1H)-ONE;8-Chloro-3H-quinazolin-4-one;4(3H)-Quinazolinone, 8-chloro-;8-chloro-3,4-dihydroquinazolin-4-one;8-CHLOROQUINAZOLIN-4(1H)-ONE, 10 mM in DMSO;8 CHLOROQUINAZOLIN 4(1H) ONE,8CHLOROQUINAZOLIN4(1H)ONE
- CBNumber
- CB62454854
- Molecular Formula
- C8H5ClN2O
- Formula Weight
- 180.59
- MOL File
- 101494-95-5.mol
8-CHLOROQUINAZOLIN-4(1H)-ONE Property
- Melting point:
- 302℃
- Boiling point:
- 327.4±44.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 0.05±0.20(Predicted)
- color
- Off-white
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C382033
- Product name
- 8-Chloroquinazolin-4(3H)-one
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- C382033
- Product name
- 8-Chloroquinazolin-4(3H)-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC142506
- Product name
- 8-Chloroquinazolin-4-ol
- Packaging
- 1g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- OR946042
- Product name
- 8-Chloroquinazolin-4(3H)-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FC142506
- Product name
- 8-Chloroquinazolin-4-ol
- Packaging
- 2g
- Price
- $135
- Updated
- 2021/12/16
8-CHLOROQUINAZOLIN-4(1H)-ONE Chemical Properties,Usage,Production
Uses
8-Chloroquinazolin-4-ol (Compd 18) is a PARP-1 enzyme inhibitor, with an IC50 of 5.65 μM[1].
Synthesis
6388-47-2
77287-34-4
101494-95-5
General procedure: 2-amino-3-chlorobenzoic acid (1 eq.) and an excess of formamide (6 eq.) were added to a three-necked flask. The reaction mixture was heated at 140 °C for 4-6 h. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, ice water was added to the mixture. The precipitated solid was filtered, washed with water and subsequently dissolved in ethyl acetate, dried over anhydrous magnesium sulfate and concentrated to give pure 8-chloroquinazolin-4-ol. If the product did not precipitate, the reaction mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated to give quinazolin-4(3H)-one derivatives 1-9,11-15,17-21 and 23. Generic method for the preparation of amino derivatives 10,16 and 22: Substituted nitroquinazolin-4(3H)-one derivatives (0.3 g, 1.56 mmol), 6 mL of ethyl acetate and stannous chloride dihydrate (2.12 g, 9.42 mmol) were added to a reaction flask and the mixture was refluxed for 8 hours. After cooling to room temperature, the reaction was quenched with saturated sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, dried over anhydrous magnesium sulfate and concentrated to afford the target amino-substituted quinazolin-4(3H)-one derivatives 10,16 and 22. The substituted o-aminobenzoic acid (1 g) was dissolved in excess acetic anhydride (10 mL) and stirred at room temperature for 4-7 h. The reaction progress was monitored by TLC. After removal of the solvent under vacuum, the residue was stirred with aqueous ammonia solution for 7 hours. After completion of the reaction, it was extracted with ethyl acetate (3 x 10 mL), the organic phases were combined, dried and concentrated with anhydrous magnesium sulfate to give compounds 26-30,31a and 32. The reduction of 2-methyl-8-nitroquinazolin-4(3H)-one intermediate (31a) to compound 31 was carried out in the same manner as described above for the synthesis of compounds 10,16 and 22.
References
[1] Shridhar S Kulkarni, et al. Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors. Eur J Med Chem. 2012 Apr:50:264-73. DOI:10.1016/j.ejmech.2012.02.001
8-CHLOROQUINAZOLIN-4(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
8-CHLOROQUINAZOLIN-4(1H)-ONE Suppliers
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 1077
- Advantage
- 64
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 0571-82896630 18969958410
- sales_hz@milestonepharmtech.com
- Country
- China
- ProdList
- 4895
- Advantage
- 55
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- +86-027-6552-2453
- sales@sun-shinechem.com
- Country
- China
- ProdList
- 727
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 0371-0371-61318675 17719817155
- Fax
- 0371-61318675
- sales@xlinebio.com
- Country
- China
- ProdList
- 2857
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- 021-021-54382182 18601603956
- 18601603956@163.com
- Country
- China
- ProdList
- 1255
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 9992
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 0371-55289822 18737195735
- Fax
- QQ:483339295
- 483339295@qq.com
- Country
- China
- ProdList
- 7587
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- 0519-68985668 13685222090
- Fax
- qq735434464
- sales@kechem.cn
- Country
- China
- ProdList
- 26028
- Advantage
- 58
- Tel
- 021-64340559 13651849907
- Fax
- 021-64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 9381
- Advantage
- 58
- Tel
- 13793517650; 13793517650
- 2767277144@qq.com
- Country
- China
- ProdList
- 2856
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 183-0212-4410 18302124410
- Djt18302124410@163.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 025-87138562 18951783565
- sales@popebiotech.com
- Country
- China
- ProdList
- 1112
- Advantage
- 58
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 7997
- Advantage
- 58
- Tel
- 15021035486 18081542813
- 1804873256@qq.com
- Country
- China
- ProdList
- 6684
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 051915240519135 13961152745
- yudiguimo@126.COM
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 029-81145305 17791533577
- 1021@dideu.com
- Country
- China
- ProdList
- 10009
- Advantage
- 58
- Tel
- 19355912709
- 690231469@qq.com
- Country
- China
- ProdList
- 7593
- Advantage
- 58
- Tel
- 400-821-026
- Sales@sangon.com
- Country
- China
- ProdList
- 6710
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- sales@coreychem.com
- Country
- China
- ProdList
- 29847
- Advantage
- 58
- Tel
- +86-2552131256 +86-18251840740
- sales@bicbiotech.com
- Country
- China
- ProdList
- 5994
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- Proteintech-CN@ptglab.com
- Country
- CHINA
- ProdList
- 6290
- Advantage
- 58
- Tel
- --
- Fax
- --
- shhebio@126.com
- Country
- CHINA
- ProdList
- 6137
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6800
- Advantage
- 58
View Lastest Price from 8-CHLOROQUINAZOLIN-4(1H)-ONE manufacturers
- Product
- 8-CHLOROQUINAZOLIN-4(1H)-ONE 101494-95-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 200KG
- Release date
- 2018-08-19