DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX

Product Name: DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX
CAS No.: 902779-59-3
Chemical Name: DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX
Synonyms: FPA 124;FPA 124,FPA124;Akt Inhibitor (FPA-124);DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX;(SP-4-3)-Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide-κN2,κS]copper
CBNumber: CB62455619
Molecular Formula: C11H10Cl2CuN3O2S
Formula Weight: 382.73
MOL File: 902779-59-3.mol

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DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Property

storage temp.: Store at +4°C
solubility: Soluble to 10 mM in DMSO and to 10 mM in ethanol
form: Powder
color: Light green to green

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18604
Product name: Akt Inhibitor XI
Purity: ≥95%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 18604
Product name: Akt Inhibitor XI
Purity: ≥95%
Packaging: 5mg
Price: $80
Updated: 2024/03/01

Cayman Chemical

Product number: 18604
Product name: Akt Inhibitor XI
Purity: ≥95%
Packaging: 10mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 18604
Product name: Akt Inhibitor XI
Purity: ≥95%
Packaging: 25mg
Price: $326
Updated: 2024/03/01

Tocris

Product number: 2926
Product name: FPA124
Packaging: 10
Price: $189
Updated: 2021/12/16

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DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Chemical Properties,Usage,Production

Description

The kinase Akt (also known as protein kinase B or PKB) modulates cell proliferation, metabolism, and survival, as well as angiogenesis. Akt inhibitor XI is a cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC₅₀s = 10-34 μM). It also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells. Molecular modeling indicates that this inhibitor interacts with the pleckstrin homology and kinase domains of Akt. Akt inhibitor XI is commonly used in the range of 1-20 μM to assess the role of Akt in cellular responses.

Uses

Akt inhibitor XI inhibits Akt in various cancer cells. Protein kinase B (PKB or Akt) is a??serene/threonine kinase, which is involved in a wide variety of cellular processes including metabolism, apoptosis and cell proliferation. Furthermore,??Akt inhibitor XI??was employed in a biological study that aimed to develop a novel coiled-coil three-hybrid system that can identify potential allosteric inhibitors.

Biological Activity

Akt/PKB inhibitor (IC 50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF- κ B activity and tumor load in vivo .

in vivo

FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells^[1].

storage

Store at +4°C

References

[1] BRENDAN D MANNING L C C. AKT/PKB signaling: navigating downstream.[J]. Cell, 2007, 129 7: 1261-1274. DOI: 10.1016/j.cell.2007.06.009
[2] T L YUAN L C C. PI3K pathway alterations in cancer: variations on a theme[J]. Oncogene, 2008, 27 41: 5497-5510. DOI: 10.1038/onc.2008.245
[3] VIVEK BARVE. Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells[J]. Journal of Medicinal Chemistry, 2006, 49 13: 3800-3808. DOI: 10.1021/jm051068y
[4] GABRIEL FRAMPTON. Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism.[J]. Gut, 2012, 61 2: 268-277. DOI: 10.1136/gutjnl-2011-300643
[5] MARK S RYBCHYN. An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts.[J]. The Journal of Biological Chemistry, 2011: 23771-23779. DOI: 10.1074/jbc.m111.251116
[6] N ZAREEN L A G S C Biswas. A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons[J]. Cell Death and Differentiation, 2013, 20 12: 1719-1730. DOI: 10.1038/cdd.2013.128

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Preparation Products And Raw materials

Raw materials

Preparation Products

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DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Suppliers

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902779-59-3, DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEXRelated Search:

Food antioxidant Natural antioxidant ANTIOXIDANT 765 CUPRIC CHLORIDE HYDRATE Cupric chloride Copper(II) chloride dihydrate DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX

FPA 124

Akt Inhibitor (FPA-124)

FPA 124,FPA124

(SP-4-3)-Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide-κN2,κS]copper

902779-59-3

C11H9Cl2CuN3O2S

Intracellular Signaling