ChemicalBook > CAS DataBase List > RILPIVIRINE HCL

RILPIVIRINE HCL

Product Name
RILPIVIRINE HCL
CAS No.
700361-47-3
Chemical Name
RILPIVIRINE HCL
Synonyms
Rilpivirine Hydrochloride;RILPIVIRINE HCL;Rilpivirine-d6 HCl;Rilpivirine HCl (TMC278;Ripivirine Hydrochloride;TMC 278. trade name Edurant
CBNumber
CB62455679
Molecular Formula
C22H19ClN6
Formula Weight
402.89
MOL File
700361-47-3.mol
More
Less

RILPIVIRINE HCL Property

storage temp. 
Store at -20°C
solubility 
DMSO:50.0(Max Conc. mg/mL);136.46(Max Conc. mM)
form 
Solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0017269
Product name
RILPIVIRINE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$501.33
Updated
2021/12/16
More
Less

RILPIVIRINE HCL Chemical Properties,Usage,Production

Uses

Rilpivirine Hydrochloride was shown to be able to treat and or prevent immunodeficiency virus-1. It also has uses for anti-viral therapy

Definition

ChEBI: A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Used for treatment of HIV.

Clinical Use

Rilpivirine hydrochloride (Edurant), a non-nucleoside reverse transcriptase inhibitor (NNRTI), received its approval both from the U.S. FDA and E.U. EMA in 2011 for the treatment of HIV-1 infection in treatment-na?ve adult patients. It was discovered and developed by Janssen Pharmaceuticals and its subsidiary Tibotec Pharmaceuticals. As a second generation NNRTI, rilpivirine hydrochloride displayed higher potency and longer half-life with a 25 mg once a day dose, compared to existing NNRTIs, such as the 200 mg BID of efavirenze (Sustiva). In late 2011, the fixed-dose combination products of rilpivirine hydrochloride with two nucleoside reverse transcriptase inhibitor (RTIs) emtricitabine and tenofovir disoproxil fumarate, co-developed by Gilead Science and Tibotec, were also approved both by the FDA and EMA under brand names Complera® and Eviplera®, respectively.

Synthesis

Similar to efavirenze, rilpivirine hydrochloride is a diarylpyrimidine (DAPY) compound, and the large-scale process synthesis begins with commercially available 2-methylthio-4-pyrimidinone (193) shown in the scheme.


Thioether 193 was condensed with neat 4-cyanoaniline (194) at elevated temperature to afford diarylamine 195 in 77% yield. Subsequent treatment of pyrimidone 195 with refluxing POCl3 provided the corresponding chloride 196 in 77% yield.160,161 In the presence of K2CO3, chloride 196 was treated with the (E)-cinnamonitrile aniline 200 to give rilpivirine hydrochloride (XIX) in good yield.158 Aniline 200 was prepared via a Heck reaction of commercially available 4-iodo-2,6-dimethyl-benzeneamine (197) and acrylonitrile (198) affording compound 199 as a 4:1 mixture of E/Z isomers. The distribution of E/Z olefins was increased to 98:2 by salt formation and recrystallization to ultimately provide pure (E)-200 in 64% yield for two steps.

RILPIVIRINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

RILPIVIRINE HCL Suppliers

Jiangxi ravel Biotechnology Co.,Ltd
Tel
185-0276-2003 18502762003;
Email
435918333@qq.com
Country
China
ProdList
2285
Advantage
58
Wuhan Beileye Biomedical Technology Co., Ltd.
Tel
18086118078
Email
2696158611@qq.com
Country
China
ProdList
4277
Advantage
58
Enlian Biomedical (Chongqing) Co., Ltd.
Tel
023-023-63134718 13983849334
Email
1501533472@qq.com
Country
China
ProdList
62
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
GIHI CHEMICALS CO.,LTD
Tel
0086-571-86217390
Fax
0086-571-86217391
Email
Sales@gihichem.com
Country
China
ProdList
860
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2769
Advantage
60
Taizhou Ruixin Chemical Co., Ltd.
Tel
0576-89085261 15867635987
Fax
0576-89085262
Email
jasonhu09@163.com
Country
China
ProdList
442
Advantage
50
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2982
Advantage
58

700361-47-3, RILPIVIRINE HCLRelated Search:


  • RILPIVIRINE HCL
  • Rilpivirine Hydrochloride
  • Rilpivirine-d6 HCl
  • Rilpivirine HCl (TMC278
  • TMC 278. trade name Edurant
  • Ripivirine Hydrochloride
  • 700361-47-3
  • C22H19ClN6
  • 700361-47-3