RILPIVIRINE HCL
- Product Name
- RILPIVIRINE HCL
- CAS No.
- 700361-47-3
- Chemical Name
- RILPIVIRINE HCL
- Synonyms
- Rilpivirine Hydrochloride;RILPIVIRINE HCL;Rilpivirine-d6 HCl;Rilpivirine HCl (TMC278;Ripivirine Hydrochloride;TMC 278. trade name Edurant
- CBNumber
- CB62455679
- Molecular Formula
- C22H19ClN6
- Formula Weight
- 402.89
- MOL File
- 700361-47-3.mol
RILPIVIRINE HCL Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);136.46(Max Conc. mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0017269
- Product name
- RILPIVIRINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.33
- Updated
- 2021/12/16
RILPIVIRINE HCL Chemical Properties,Usage,Production
Uses
Rilpivirine Hydrochloride was shown to be able to treat and or prevent immunodeficiency virus-1. It also has uses for anti-viral therapy
Definition
ChEBI: A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Used for treatment of HIV.
Clinical Use
Rilpivirine hydrochloride (Edurant), a non-nucleoside reverse transcriptase inhibitor (NNRTI), received its approval both from the U.S. FDA and E.U. EMA in 2011 for the treatment of HIV-1 infection in treatment-na?ve adult patients. It was discovered and developed by Janssen Pharmaceuticals and its subsidiary Tibotec Pharmaceuticals. As a second generation NNRTI, rilpivirine hydrochloride displayed higher potency and longer half-life with a 25 mg once a day dose, compared to existing NNRTIs, such as the 200 mg BID of efavirenze (Sustiva). In late 2011, the fixed-dose combination products of rilpivirine hydrochloride with two nucleoside reverse transcriptase inhibitor (RTIs) emtricitabine and tenofovir disoproxil fumarate, co-developed by Gilead Science and Tibotec, were also approved both by the FDA and EMA under brand names Complera® and Eviplera®, respectively.
Synthesis
Similar to efavirenze, rilpivirine hydrochloride is a diarylpyrimidine (DAPY) compound, and the large-scale process synthesis begins with commercially available 2-methylthio-4-pyrimidinone (193) shown in the scheme.
Thioether 193 was condensed with neat 4-cyanoaniline (194) at elevated temperature to afford diarylamine 195 in 77% yield. Subsequent treatment of pyrimidone 195 with refluxing POCl3 provided the corresponding chloride 196 in 77% yield.160,161 In the presence of K2CO3, chloride 196 was treated with the (E)-cinnamonitrile aniline 200 to give rilpivirine hydrochloride (XIX) in good yield.158 Aniline 200 was prepared via a Heck reaction of commercially available 4-iodo-2,6-dimethyl-benzeneamine (197) and acrylonitrile (198) affording compound 199 as a 4:1 mixture of E/Z isomers. The distribution of E/Z olefins was increased to 98:2 by salt formation and recrystallization to ultimately provide pure (E)-200 in 64% yield for two steps.
RILPIVIRINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
RILPIVIRINE HCL Suppliers
- Tel
- 185-0276-2003 18502762003;
- 435918333@qq.com
- Country
- China
- ProdList
- 2285
- Advantage
- 58
- Tel
- 18086118078
- 2696158611@qq.com
- Country
- China
- ProdList
- 4277
- Advantage
- 58
- Tel
- 023-023-63134718 13983849334
- 1501533472@qq.com
- Country
- China
- ProdList
- 62
- Advantage
- 58
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- 0086-571-86217390
- Fax
- 0086-571-86217391
- Sales@gihichem.com
- Country
- China
- ProdList
- 860
- Advantage
- 58
- Tel
- 0523-18601685-898 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2769
- Advantage
- 60
- Tel
- 0576-89085261 15867635987
- Fax
- 0576-89085262
- jasonhu09@163.com
- Country
- China
- ProdList
- 442
- Advantage
- 50
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2982
- Advantage
- 58