6-(HYDROXYMETHYL)NICOTINONITRILE

Product Name: 6-(HYDROXYMETHYL)NICOTINONITRILE
CAS No.: 31795-61-6
Chemical Name: 6-(HYDROXYMETHYL)NICOTINONITRILE
Synonyms: (5-Cyano-pyridin-2-yl)methanol;6-(HYDROXYMETHYL)NICOTINONITRILE;5-Cyano-2-(hydroxymethyl)-pyridine;6-Hydroxymethylpyridine-3-carbonitrile;6-(hydroxymethyl)-3-Pyridinecarbonitrile;6-(Hydroxymethyl)-pyridin-3-carbonitrile;3-Pyridinecarbonitrile, 6-(hydroxymethyl)-
CBNumber: CB62455806
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 31795-61-6.mol

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6-(HYDROXYMETHYL)NICOTINONITRILE Property

Boiling point:: 303.1±32.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 13.06±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H804555
Product name: 6-(Hydroxymethyl)nicotinonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: H804555
Product name: 6-(Hydroxymethyl)nicotinonitrile
Packaging: 1g
Price: $160
Updated: 2021/12/16

TRC

Product number: H804555
Product name: 6-(Hydroxymethyl)nicotinonitrile
Packaging: 2.5g
Price: $315
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391356
Product name: 6-(HYDROXYMETHYL)NICOTINONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $503.15
Updated: 2021/12/16

AK Scientific

Product number: 3483AB
Product name: 6-(Hydroxymethyl)nicotinonitrile
Packaging: 1g
Price: $590
Updated: 2021/12/16

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6-(HYDROXYMETHYL)NICOTINONITRILE Chemical Properties,Usage,Production

Uses

6-(Hydroxymethyl)nicotinonitrile is the derivative of 5-Cyano-2-methylpyridine (C981875), which is used to synthesize acridone-based inhibitors of inosine 5''-monophosphate dehydrogenase (IMPDH). It is also used in the preparation of potent and selective nonpeptidic inhibitors of procollagen C-proteinase.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Synthesis

31795-60-5

31795-61-6

The general procedure for synthesizing 6-hydroxymethylpyridine-3-carbonitrile from the compound (CAS: 31795-60-5) was as follows: the compound of Example 31A (180 mg, 1.02 mmol) was dissolved in tetrahydrofuran (8 mL). Lithium hydroxide (48.94 mg, 2.04 mmol) was dissolved in water (5 mL) and this aqueous solution was added to the tetrahydrofuran solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was diluted with water and ethyl acetate. The aqueous phase was extracted three times with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over magnesium sulfate monohydrate, filtered and concentrated in vacuum. The resulting residue was used in the next reaction without further purification. Yield: 125 mg (91% yield). HPLC (Method 8): retention time (Rt) = 1.17 min. mass spectra (DCI): m/z 152 ([M + NH4]+). 1H-NMR (300 MHz, DMSO-d6): δ = 4.63 (d, 2H); 5.64 (t, 1H); 7.65 (d, 1H); 8.29 (dd, 1H); 8.92 (d, 1H) ppm.

References

[1] Patent: WO2004/20412, 2004, A1. Location in patent: Page 47

6-(HYDROXYMETHYL)NICOTINONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(HYDROXYMETHYL)NICOTINONITRILE Suppliers

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View Lastest Price from 6-(HYDROXYMETHYL)NICOTINONITRILE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-(HYDROXYMETHYL)NICOTINONITRILE 31795-61-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

31795-61-6, 6-(HYDROXYMETHYL)NICOTINONITRILERelated Search:

6-(DIMETHOXYMETHYL)-2-MERCAPTONICOTINONITRILE METHYL 5-CYANO-2-(DIMETHOXYMETHYL)-6-(2,2,2-TRIFLUOROETHYLTHIO)NICOTINATE 6-(DIMETHOXYMETHYL)-2-HYDROXYNICOTINONITRILE RARECHEM AL BI 1034 RARECHEM AL BE 1034 METHYL 5-CYANO-2-(DIMETHOXYMETHYL)-6-MERCAPTONICOTINATE 2-HYDROXY-6-[1-(4-METHOXYPHENOXY)ETHYL]NICOTINONITRILE RARECHEM AL BP 1034 AKOS B030610 6-(1,1-DIMETHOXYETHYL)-2-MERCAPTONICOTINONITRILE AKOS B030613 AKOS B030614 AKOS B030611 6-[1-(4-CHLOROPHENOXY)ETHYL]-2-HYDROXYNICOTINONITRILE SPECS AP-782/41885530 2-HYDROXY-6-[1-(3-PYRIDINYLOXY)ETHYL]NICOTINONITRILE AKOS B030612 RARECHEM AL BF 1034

6-(hydroxymethyl)-3-Pyridinecarbonitrile

(5-Cyano-pyridin-2-yl)methanol

6-Hydroxymethylpyridine-3-carbonitrile

6-(HYDROXYMETHYL)NICOTINONITRILE

3-Pyridinecarbonitrile, 6-(hydroxymethyl)-

5-Cyano-2-(hydroxymethyl)-pyridine

6-(Hydroxymethyl)-pyridin-3-carbonitrile

31795-61-6