5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 27383-92-2
- Chemical Name
- 5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 5-chloro-2-benzoxazolecarboxylate;methyl 5-chlorobenzo[d]oxazole-2-carboxylate;methyl 5-chloro-1,3-benzoxazole-2-carboxylate;5-Chloro-2-benzoxazolecarboxylic acid methyl ester;5-chloro-benzoxazole-2-carboxylic acid methyl ester;5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER;2-Benzoxazolecarboxylic acid, 5-chloro-, Methyl ester
- CBNumber
- CB62457648
- Molecular Formula
- C9H6ClNO3
- Formula Weight
- 211.6
- MOL File
- 27383-92-2.mol
5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 124 °C
- Boiling point:
- 309.1±34.0 °C(Predicted)
- Density
- 1.416
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.88±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2595AB
- Product name
- Methyl5-chlorobenzo[d]oxazole-2-carboxylate
- Packaging
- 250mg
- Price
- $455
- Updated
- 2021/12/16
- Product number
- HCH0105217
- Product name
- 5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Purity
- 96.00%
- Packaging
- 250MG
- Price
- $852.39
- Updated
- 2021/12/16
- Product number
- 144571
- Product name
- Methyl 5-chlorobenzo[d]oxazole-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $1425
- Updated
- 2021/12/16
- Product number
- 144571
- Product name
- Methyl 5-chlorobenzo[d]oxazole-2-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $3995
- Updated
- 2021/12/16
- Product number
- A268528
- Product name
- Methyl5-chlorobenzo[d]oxazole-2-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $117
- Updated
- 2021/12/16
5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
124-38-9
74-88-4
17200-29-2
27383-92-2
Catalyst (9.9 mg, 0.025 mmol, 5 mol%), potassium tert-butoxide (0.0672 g, 0.6 mmol), DMF (3.0 mL), and 5-chlorobenzoxazole (76.79 mg, 0.5 mmol) were added to the reaction flask under argon protection. The reaction mixture was stirred at 80 °C for 18 h under carbon dioxide atmosphere at atmospheric pressure. Upon completion of the reaction, the system was cooled to 65 °C, followed by the addition of iodomethane (93 μL, 1.5 mmol) and continued stirring at 65 °C for 1 hour. At the end of the reaction, the system was cooled to room temperature and the reaction was quenched with deionized water. The reaction mixture was extracted with ethyl acetate, and the organic phases were combined and purified by column chromatography (Expanding agent: ethyl acetate/petroleum ether, 1:10, v/v). The target product methyl 5-chlorobenzoxazole-2-carboxylate was finally obtained in 82% yield.
References
[1] Organic Letters, 2010, vol. 12, # 15, p. 3567 - 3569
[2] Green Chemistry, 2018, vol. 20, # 5, p. 989 - 996
[3] Patent: CN106565623, 2017, A. Location in patent: Paragraph 0038
[4] Green Chemistry, 2013, vol. 15, # 3, p. 635 - 640
5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Suppliers
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- Product
- 5-CHLORO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER 27383-92-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08