1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
Uses- Product Name
- 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 24334-19-8
- Chemical Name
- 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 6-azaindole-2-carbo...;Ethyl 6-azaindole-2-carboxylate;1H-pyrrolo[2,3-c]pyridine-2-carboxylate;6-azaindole-2-carboxylic acid ethyl ester;(E)-ethyl 3-(3-aminopyridin-4-yl)acrylate;ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate;ethyl 1H-pyrrolo[2,3-c]pyridine-2-carbo×ylate;ETHYL 1H-PYRR0L0E2, 3- C]PYRIDINE-2-CARB0XYLATE;1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB62458357
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 24334-19-8.mol
1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 207-208 °C
- Boiling point:
- 371.8±22.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.67±0.40(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E927680
- Product name
- Ethyl1H-Pyrrolo[2,3-c]pyridine-2-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR922142
- Product name
- Ethyl1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 1795AB
- Product name
- Ethyl1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- Packaging
- 1g
- Price
- $351
- Updated
- 2021/12/16
- Product number
- 4H58-1-J2
- Product name
- Ethyl 6-azaindole-2-carboxylate
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- OR922142
- Product name
- Ethyl1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $555
- Updated
- 2021/12/16
1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate is a useful research chemical.
Synthesis
95-92-1
180253-66-1
24334-19-8
1. tert-Butyl (4-methylpyridin-3-yl)carbamate (3.5 g, 16.8 mmol) was dissolved in anhydrous THF (30 ml) and cooled to -40 °C under argon protection. 2. tert-butyl lithium (20.7 ml, 1.7 M pentane solution, 35.2 mmol) was added slowly and the reaction mixture was kept stirred at -40 °C for 1 hour. 3. A solution of diethyl oxalate (2.5 ml, 18.5 mmol) in THF (30 ml) was added dropwise over 15 min. 4. the reaction mixture was warmed to 0 °C and stirring was continued for 2 h. The reaction mixture was then slowly warmed to room temperature and stirred for 19 h. The reaction mixture was then stirred for 1 h. The reaction mixture was then slowly warmed to room temperature. 5. 2N HCl (110 ml) was carefully added to the reaction mixture and heated to reflux for 2 hours. 6. After cooling, the organic phase was extracted by adding dichloromethane (100 ml) and the aqueous phase pH was adjusted to 8 and the organic phase was separated. 7. The aqueous phase was washed with dichloromethane (2 x 50 ml), the organic layers were combined, dried with magnesium sulfate and concentrated to give a light brown solid. 8. The solid was ground with ethyl acetate and the beige solid product (586 mg, 18%) was collected by filtration. LCMS (Method B): RT = 1.89min, M + H + = 190.
References
[1] Patent: US2010/216768, 2010, A1. Location in patent: Page/Page column 16-17
1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 24334-19-8
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24