ChemicalBook > CAS DataBase List > 7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin

Product Name
7-Ethyl-10-hydroxycamptothecin
CAS No.
130144-34-2
Chemical Name
7-Ethyl-10-hydroxycamptothecin
Synonyms
Camptothecin Impurity 21;7-Ethyl-10-hydroxycamptothecin;(rac)-7-Ethyl-10-Hydroxy camptothecin;rac-4,11-Diethyl-9-hydroxycamptothecin;7-Ethyl-10-hydroxycamptothecin, racemic;(110714-48-2) 7-ethyl-10-hydroxycamptothecin;1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CBNumber
CB62462141
Molecular Formula
C22H20N2O5
Formula Weight
392.41
MOL File
130144-34-2.mol
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7-Ethyl-10-hydroxycamptothecin Property

Boiling point:
810.3±65.0 °C(Predicted)
Density 
1.51
pka
9.13±0.40(Predicted)
InChI
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3
InChIKey
FJHBVJOVLFPMQE-UHFFFAOYSA-N
SMILES
N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O
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Hazard and Precautionary Statements (GHS)

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7-Ethyl-10-hydroxycamptothecin Chemical Properties,Usage,Production

Description

7-Ethyl-10-hydroxycamptothecin: a potent topoisomerase I inhibitor
7-Ethyl-10-hydroxycamptothecin (SN-38), as a highly active topoisomerase (Topo) I inhibitor, is the active metabolic product of its prodrug irinotecan (CPT-11) commercially available as Camptosar. By combining with the Topo I-DNA covalent conjugate, the camptothecin analogue forms a ternary complex that blocks the repolymerization of the DNA strands during their replication, eventually leading to the cell apoptosis. Although SN-38 is about 100- to 1000-fold more potent than irinotecan, its clinical application is limited by its poor solubility and nonspecific toxicity[1].

Definition

ChEBI: LSM-6189 is a pyranoindolizinoquinoline.

References

[1] Shuangxi Liu. “Co-Prodrugs of 7-Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects.” ACS Omega 5 1 (2019): 350–357.

7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Ethyl-10-hydroxycamptothecin manufacturers

Career Henan Chemical Co
Product
4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 130144-34-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

130144-34-2, 7-Ethyl-10-hydroxycamptothecinRelated Search:


  • 7-Ethyl-10-hydroxycamptothecin
  • 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-
  • (110714-48-2) 7-ethyl-10-hydroxycamptothecin
  • (rac)-7-Ethyl-10-Hydroxy camptothecin
  • rac-4,11-Diethyl-9-hydroxycamptothecin
  • 7-Ethyl-10-hydroxycamptothecin, racemic
  • Camptothecin Impurity 21
  • 130144-34-2
  • 86639-52-8
  • 86639-52-2