BZ-NLE-LYS-ARG-ARG-AMC
- Product Name
- BZ-NLE-LYS-ARG-ARG-AMC
- CAS No.
- 863975-32-0
- Chemical Name
- BZ-NLE-LYS-ARG-ARG-AMC
- Synonyms
- Bz-nLKRR-AMC;Bz-Nle-KRR-AMC;BZ-NLE-LYS-ARG-ARG-AMC;Bz-Nle-KRR-AMC (hydrochloride);Bz-Nle-Lys-Arg-Arg-AMC trifluoroacetate salt;BZ-NLKRR-AMC;BZ-NLE-LYS-ARG-ARG-AMC;863975-32-0;L-Argininamide, N-benzoyl-L-norleucyl-L-lysyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
- CBNumber
- CB62466846
- Molecular Formula
- C41H60N12O7
- Formula Weight
- 832.99
- MOL File
- 863975-32-0.mol
BZ-NLE-LYS-ARG-ARG-AMC Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
- form
- A solid
- Sequence
- {Bz-Nle}-Lys-Arg-Arg-AMC
N-Bromosuccinimide Price
- Product number
- 27710
- Product name
- Bz-Nle-KRR-AMC (hydrochloride)
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 27710
- Product name
- Bz-Nle-KRR-AMC (hydrochloride)
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 27710
- Product name
- Bz-Nle-KRR-AMC (hydrochloride)
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 27710
- Product name
- Bz-Nle-KRR-AMC (hydrochloride)
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- FB110611
- Product name
- Bz-Nle-Lys-Arg-Arg-AMC trifluoroacetate salt
- Packaging
- 1mg
- Price
- $328
- Updated
- 2021/12/16
BZ-NLE-LYS-ARG-ARG-AMC Chemical Properties,Usage,Production
Description
Bz-Nle-KRR-AMC is a fluorogenic peptide substrate for yellow fever virus (YFV) non-structural 3 (NS3) and dengue virus (DV) NS2B/3 serine proteases. Upon enzymatic cleavage by YFV NS3 or DV NS2B/3 serine proteases, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify YFV NS3 or DV NS2B/3 serine protease activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Uses
Bz-Nle-Lys-Arg-Arg-AMC can be used for protease activity assay. In 0.1mL Tris-HCl buffer (50 mM, pH 7.8), Bz-Nle-Lys-Arg-Arg-AMC was hydrolyzed, and the release rate of AMC was observed and calculated at λex/λem=380 nm/460 nm[1].
References
[1] Phoo WW, et al. Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3. Antiviral Res. 2020 Oct;182:104900. DOI:10.1016/j.antiviral.2020.104900
BZ-NLE-LYS-ARG-ARG-AMC Preparation Products And Raw materials
Raw materials
Preparation Products
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