ChemicalBook > CAS DataBase List > TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE

Uses

Product Name: TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
CAS No.: 149771-43-7
Chemical Name: TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
Synonyms: 8-Boc-3-benzyl-3,8-diazabicyclo[3.2.1]octane;3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane;TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE;3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(phenylMethyl)-, 1,1-diMethylethyl ester
CBNumber: CB62467656
Molecular Formula: C18H26N2O2
Formula Weight: 302.41
MOL File: 149771-43-7.mol

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TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Property

Boiling point:: 393.4±35.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.57±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 1031CW
Product name: Tert-butyl3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
Packaging: 250mg
Price: $173
Updated: 2021/12/16

Matrix Scientific

Product number: 175848
Product name: tert-Butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
Packaging: 1g
Price: $540
Updated: 2021/12/16

Matrix Scientific

Product number: 175848
Product name: tert-Butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
Packaging: 5g
Price: $1296
Updated: 2021/12/16

Matrix Scientific

Product number: 175848
Product name: tert-Butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate
Packaging: 10g
Price: $1872
Updated: 2021/12/16

J&W Pharmlab

Product number: 75R0766
Product name: 3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane
Purity: 97%
Packaging: 5g
Price: $2390
Updated: 2021/12/16

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TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Chemical Properties,Usage,Production

Uses

3-Benzyl-8-(tert-butoxycarbonyl)-3,8-diazabicyclo[3.2.1]-octane is a hydrocarbon derivative that can be used as a pharmaceutical intermediate.

Synthesis

24424-99-5

67571-90-8

149771-43-7

3-Benzyl-3,8-diazabicyclo[3.2.1]octane (13.5 g, 66.7 mmol) was used as starting material and mixed with triethylamine (6.75 g, 66.7 mmol) and di-tert-butyl dicarbonate (14.56 g, 66.7 mmol) in dichloromethane (100 ml). The reaction mixture was stirred under cooling in an ice bath for 3 hours. After completion of the reaction, the crude product was washed with water (150 ml) and the aqueous phase was then extracted with dichloromethane (50 ml). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (13 g, 65% yield). The melting point of the product was 58-60°C.

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 674 - 681
[2] Farmaco, 1993, vol. 48, # 3, p. 387 - 396
[3] Patent: EP1213289, 2002, A1. Location in patent: Page 12
[4] Patent: WO2006/106090, 2006, A1. Location in patent: Page/Page column 16
[5] Farmaco, 1998, vol. 53, # 8-9, p. 557 - 562

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Suppliers

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149771-43-7, TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATERelated Search:

3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(phenylMethyl)-, 1,1-diMethylethyl ester

8-Boc-3-benzyl-3,8-diazabicyclo[3.2.1]octane

149771-43-7