9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]-

Product Name: 9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]-
CAS No.: 924296-17-3
Chemical Name: 9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]-
Synonyms: DUB-IN-3;DUBs-IN-3;USP8-IN-22c;DUBs inhibitor 3;DUB-IN-3, 10 mM in DMSO;DUBs,inhibit,Deubiquitinase,DUBIN3,Inhibitor,DUB IN 3;9-(Allyloxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile;9-[(2-Propen-1-yloxy)imino]-9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile;9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]-
CBNumber: CB62468491
Molecular Formula: C16H9N5O
Formula Weight: 287.28
MOL File: 924296-17-3.mol

More

Less

9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]- Property

storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (87.02 mM; Need ultrasonic)
form: Powder
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: B3516
Product name: DUBs-IN-3
Packaging: 2mg
Price: $342
Updated: 2021/12/16

ChemScene

Product number: CS-2847
Product name: DUB-IN-3
Purity: 99.00%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ApexBio Technology

Product number: B3516
Product name: DUBs-IN-3
Packaging: 5mg
Price: $512
Updated: 2021/12/16

ChemScene

Product number: CS-2847
Product name: DUB-IN-3
Purity: 99.00%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611806
Product name: USP8-IN-22c
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

More

Less

9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]- Chemical Properties,Usage,Production

Description

DUB-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8; IC50 = 0.56 µM).1 It is selective for USP8 over USP7 (IC50 = >100 µM). DUB-IN-3 is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro) when Z-LRGG-AMC is used as a substrate (IC50 = 12.5 µM) but not when the larger substrate Ub-AMC is used (IC50 = >10 µM).2 It reduces glutathione (GSH) levels and cystine uptake, as well as increases ferrous iron and reactive oxygen species (ROS) levels, in HCCLM3 cells when used at concentrations of 0.2 or 0.5 µM.3 It decreases the viability of HCCLM3 cells when used in combination with the ferroptosis inducer RSL3 (Item No. 19288), an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 (Item No. 17729). DUB-IN-3 (0.1 and 0.2 µM) reduces the proliferation, migration, and oncosphere formation ability of HCCLM3 and Hep3B hepatocellular carcinoma cells. It also reduces tumor growth and metastasis in HCCLM3 and Hep3B mouse models of metastatic lung cancer when administered at a dose of 5 mg/kg per day.WARNING This product is not for human or veterinary use.

9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]- Suppliers

China 44 United States 6 Global 50

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

924296-17-3, 9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]-Related Search:

9H-INDENO[1,2-B]PYRAZINE-2,3-DICARBONITRILE, 9-[(2-PROPEN-1-YLOXY)IMINO]-

9-[(2-Propen-1-yloxy)imino]-9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile

DUBs-IN-3

USP8-IN-22c

9-(Allyloxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

DUBs inhibitor 3

DUB-IN-3

DUBs,inhibit,Deubiquitinase,DUBIN3,Inhibitor,DUB IN 3

DUB-IN-3, 10 mM in DMSO

924296-17-3