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Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate

Product Name
Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate
CAS No.
50889-46-8
Chemical Name
Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate
Synonyms
1-dimethoxyphosphoryl-3,3-difluoroheptan-2-one;Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate;Dimethyl (2-oxo-3,3-difluoroheptyl)phosphonate;Dimethyl (3,3-difluoro-2-oxohept-1-yl)phosphonate;Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate 97%;(3,3-Difluoro-2-oxoheptyl)phosphonic acid dimethyl ester;TIANFU CHEM--Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate;Phosphonic acid, P-(3,3-difluoro-2-oxoheptyl)-, dimethyl ester
CBNumber
CB62470276
Molecular Formula
C9H17F2O4P
Formula Weight
258.2
MOL File
50889-46-8.mol
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Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate Property

Boiling point:
301.0±37.0 °C(Predicted)
Density 
1.162
refractive index 
1.42
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Dichloromethane, Chloroform, Ethyl Acetate, Tetrahydrofuran
form 
Oil
color 
Orange
InChI
InChI=1S/C9H17F2O4P/c1-4-5-6-9(10,11)8(12)7-16(13,14-2)15-3/h4-7H2,1-3H3
InChIKey
CISDEVRDMKWPCP-UHFFFAOYSA-N
SMILES
P(CC(=O)C(F)(F)CCCC)(=O)(OC)OC
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Safety

HS Code 
2931599090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5176
Product name
Dimethyl (3,3-Difluoro-2-oxoheptyl)phosphonate
Purity
>98.0%(GC)
Packaging
200mg
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
D5176
Product name
Dimethyl (3,3-Difluoro-2-oxoheptyl)phosphonate
Purity
>98.0%(GC)
Packaging
1g
Price
$234
Updated
2025/07/31
TRC
Product number
D471800
Product name
Dimethyl (3,3-Difluoro-2-oxoheptyl)phosphonate
Packaging
100mg
Price
$1260
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0044356
Product name
DIMETHYL (3,3-DIFLUORO-2-OXOHEPTYL)PHOSPHONATE
Purity
95.00%
Packaging
100MG
Price
$1600
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0044356
Product name
DIMETHYL (3,3-DIFLUORO-2-OXOHEPTYL)PHOSPHONATE
Purity
95.00%
Packaging
250MG
Price
$4150
Updated
2021/12/16
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Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate Chemical Properties,Usage,Production

Chemical Properties

Orange Oil

Uses

Dimethyl(3,3-difluoro-2-oxoheptyl)phosphonate (cas# 50889-46-8) is a compound useful in organic synthesis.

Synthesis

74106-81-3

756-79-6

50889-46-8

General procedure for the synthesis of dimethyl (2-oxo-3,3-difluoroheptyl) phosphonate from ethyl 2,2-difluorohexanoate and dimethyl methylphosphonate: Dimethyl methylphosphonate (215 mL) was dissolved in tetrahydrofuran (THF, 1450 mL), stirred and the reaction solution was cooled to -78 °C. Slowly n-butyllithium (N-BuLi, 804 mL) was added dropwise and stirring was continued for 2 hours. Subsequently, ethyl 2,2-difluorohexanoate (145 g) was added dropwise. The reaction mixture was stirred at -78 °C for some time, then slowly warmed to 0 °C and continued stirring for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio hexane: ethyl acetate = 1:1). Upon completion of the reaction, the reaction was diluted with the addition of pentane (1000 mL) and the pH was adjusted to 6 with 2 M sulfuric acid solution.The aqueous layer was separated and the organic layer was re-extracted with pentane. The organic layer was combined and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent ratio hexane:ethyl acetate=1:1) to afford pure dimethyl (2-oxo-3,3-difluoroheptyl)phosphonate (161 g, 78% yield).

References

[1] Patent: KR2016/70457, 2016, A. Location in patent: Paragraph 0161; 0162
[2] Patent: US2010/56807, 2010, A1. Location in patent: Page/Page column 6

Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate Suppliers

Americas 1 Canada 1 China 102 Europe 1 France 1 India 3 Japan 1 United Kingdom 3 United States 8 Global 121
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate 50889-46-8
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-17
Shaanxi Dideu New Materials Co. Ltd
Product
Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate 50889-46-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-11
Henan Aochuang Chemical Co.,Ltd.
Product
Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate 50889-46-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09

50889-46-8, Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonateRelated Search:


  • Dimethyl (2-oxo-3,3-difluoroheptyl)phosphonate
  • Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate
  • (3,3-Difluoro-2-oxoheptyl)phosphonic acid dimethyl ester
  • Dimethyl (3,3-difluoro-2-oxohept-1-yl)phosphonate
  • Phosphonic acid, P-(3,3-difluoro-2-oxoheptyl)-, dimethyl ester
  • 1-dimethoxyphosphoryl-3,3-difluoroheptan-2-one
  • TIANFU CHEM--Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate
  • Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate 97%
  • 50889-46-8
  • C9H17F2O4P
  • Miscellaneous Reagents