6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Product Name: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS No.: 943994-02-3
Chemical Name: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Synonyms: -2H-benzo[b][1,4]oxazin-3(4H);3-Oxo-2H,4H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester;6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-1,4-benzo...;3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester;3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic Acid Pinacol Ester;6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4H-1,4-benzoxazin-3-one;6-(4,4,5,5-tetraMethyl-1-3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one;6-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4- dihydro-2H-1,4-benzoxazin-3-one;2H-1,4-Benzoxazin-3(4H)-one,6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CBNumber: CB62470498
Molecular Formula: C14H18BNO4
Formula Weight: 275.11
MOL File: 943994-02-3.mol

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one Property

Boiling point:: 441.1±45.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.75±0.20(Predicted)
form: Solid
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BOR0002276
Product name: 6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
Purity: 95.00%
Packaging: 1G
Price: $574.35
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0002276
Product name: 6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0002276
Product name: 6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

Matrix Scientific

Product number: 175243
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one
Packaging: 5g
Price: $1386
Updated: 2021/12/16

Matrix Scientific

Product number: 175243
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one
Packaging: 10g
Price: $2070
Updated: 2021/12/16

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one Chemical Properties,Usage,Production

Synthesis

24036-52-0

73183-34-3

943994-02-3

6-Bromo-2H-1,4-benzoxazin-3(4H)-one (2.3 g, 10 mmol) and pinacol ester of bis(boronic acid) (3.05 g, 12 mmol) were used as raw materials, which were dissolved in dioxane (20 mL), and then potassium acetate (2 g, 20 mmol) and Pd(dppf)Cl2 (730 mg, 1 mmol) were added sequentially. The reaction system was purged with nitrogen and the reaction was stirred at 90 °C overnight. After completion of the reaction, the mixture was diluted with ethyl acetate (200 mL) and filtered. The organic phase was sequentially washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=3:1) to afford 3-oxo-2H,4H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester (1.9 g, 69% yield).

References

[1] Patent: WO2015/153683, 2015, A1. Location in patent: Paragraph 0937
[2] Patent: WO2017/211303, 2017, A1. Location in patent: Page/Page column 36
[3] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 55-56
[4] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 227
[5] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 3281-3283

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one Suppliers

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View Lastest Price from 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one manufacturers

Career Henan Chemical Co

Product: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 943994-02-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

943994-02-3, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-oneRelated Search:

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one

3-Oxo-2H,4H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester

6-(4,4,5,5-tetraMethyl-1-3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one

6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-4H-1,4-benzoxazin-3-one

3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester

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6-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4- dihydro-2H-1,4-benzoxazin-3-one

3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)boronate

3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic Acid Pinacol Ester

-2H-benzo[b][1,4]oxazin-3(4H)

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-1,4-benzo...

943994-02-3