ChemicalBook > CAS DataBase List > 5,6-difluoroindoline
5,6-difluoroindoline
- Product Name
- 5,6-difluoroindoline
- CAS No.
- 954255-04-0
- Chemical Name
- 5,6-difluoroindoline
- Synonyms
- 5,6-difluoroindoline;5,6-difluoro-2,3-dihydro-1H-indole;1H-Indole, 5,6-difluoro-2,3-dihydro-
- CBNumber
- CB62470625
- Molecular Formula
- C8H7F2N
- Formula Weight
- 155.14
- MOL File
- 954255-04-0.mol
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5,6-difluoroindoline Property
- Boiling point:
- 207.0±40.0 °C(Predicted)
- Density
- 1.261±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.30±0.20(Predicted)
- Appearance
- White to off-white Solid
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- D456245
- Product name
- 5,6-Difluoroindoline
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
TRC
- Product number
- D456245
- Product name
- 5,6-Difluoroindoline
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H31-3-6A
- Product name
- 5,6-Difluoroindoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $223
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 090267
- Product name
- 5,6-Difluoroindoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $319
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0054134
- Product name
- 5,6-DIFLUOROINDOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $425.25
- Updated
- 2021/12/16
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5,6-difluoroindoline Chemical Properties,Usage,Production
Synthesis
169674-01-5
954255-04-0
General procedure for the synthesis of 5,6-difluoroindoline from 5,6-difluoroindole: 0.30 g (1.8 mmol) of 5,6-difluoroindole was dissolved in 10 mL of tetrahydrofuran (THF) under the protection of argon gas and 3.0 mL of 1 M borane-THF solution was added slowly and dropwise. Subsequently, the reaction mixture was heated to 70 °C and maintained for 2 h, after which it was cooled to room temperature. To the reaction mixture, 3 mL of methanol was added, followed by 5 mL of aqueous 4N hydrochloric acid solution, and the mixture was refluxed for 1 hour. Upon completion of the reaction, the organic phase was removed by evaporation and the aqueous phase was washed with dichloromethane (DCM) and then alkalized with 4N aqueous sodium hydroxide solution, followed by multiple extractions with ethyl acetate (EtOAc). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The product was obtained as 160 mg in 47% yield. eSI-MS: m/z = 156 (M + H)+; HPLC-MS retention time (Method C): 0.73 min.
References
[1] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 47
5,6-difluoroindoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-difluoroindoline manufacturers
Career Henan Chemical Co
- Product
- 5,6-difluoroindoline 954255-04-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 2kg；10kg; 100kg
- Release date
- 2019-08-30