2-chloro-4-fluoro-3-methylbenzonitrile
- Product Name
- 2-chloro-4-fluoro-3-methylbenzonitrile
- CAS No.
- 796600-15-2
- Chemical Name
- 2-chloro-4-fluoro-3-methylbenzonitrile
- Synonyms
- 2-Chlor-4-fluor-3-methylbenzonitril;2-chloro-3-methyl-4-fluorobenzonitrile;2-chloro-4-fluoro-3-methylbenzonitrile;Benzonitrile, 2-chloro-4-fluoro-3-methyl-
- CBNumber
- CB62473343
- Molecular Formula
- C8H5ClFN
- Formula Weight
- 169.58
- MOL File
- 796600-15-2.mol
2-chloro-4-fluoro-3-methylbenzonitrile Property
- Melting point:
- 54-58°C
- Boiling point:
- 260.8±35.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
- InChI
- InChI=1S/C8H5ClFN/c1-5-7(10)3-2-6(4-11)8(5)9/h2-3H,1H3
- InChIKey
- IOKBJSAKTZEMBR-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC=C(F)C(C)=C1Cl
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C367315
- Product name
- 2-Chloro-4-fluoro-3-methylbenzonitrile
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- C367315
- Product name
- 2-Chloro-4-fluoro-3-methylbenzonitrile
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 073789
- Product name
- 2-Chloro-4-fluoro-3-methylbenzonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- FC104829
- Product name
- 2-chloro-4-fluoro-3-methylbenzonitrile
- Packaging
- 5G
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC104829
- Product name
- 2-chloro-4-fluoro-3-methylbenzonitrile
- Packaging
- 10g
- Price
- $150
- Updated
- 2021/12/16
2-chloro-4-fluoro-3-methylbenzonitrile Chemical Properties,Usage,Production
Uses
2-Chloro-4-fluoro-3-methylbenzonitrile is a reagent used in the synthesis of a novel and potent nonsteroidal androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.
Synthesis
60702-69-4
74-88-4
796600-15-2
General procedure for the synthesis of 2-chloro-3-methyl-4-fluorobenzonitrile from 2-chloro-4-fluorobenzonitrile and iodomethane: First, a tetrahydrofuran (THF, 1 L) solution of diisopropylamine (80.6 mL, 0.575 mol) was cooled down to about -5 °C in an ice water/methanol bath. Subsequently, n-butyllithium (2.5 M hexane solution, 212 mL, 0.530 mol) was slowly added over a period of 1 h using a syringe pump (4 mL/min) while maintaining the reaction temperature between -5 and 0°C. The lithium diisopropylammonium (LDA) solution was stirred at 0 °C for 1 h and then transferred to a THF (1 L) solution of 2-chloro-4-fluorobenzonitrile (68.7 g, 0.442 mol) pre-cooled to -78 °C via cannulae over a 1 h period. The temperature of the reaction mixture may rise to about -65 °C during the initial addition of the LDA solution, but the internal temperature needs to be ensured to be below -70 °C during the remaining LDA addition. The temperature of the resulting dark red-orange reaction mixture was maintained below -70 °C for 5 h. Iodomethane (251.2 g, 1.77 mol) was then added at a rate of about 3 mL/min, with the rate of addition being controlled to maintain the reaction temperature below -65 °C. Afterwards, the reaction mixture was allowed to slowly warm up overnight. After stirring for 14 hours, the temperature of the reaction mixture reached -5 °C. The reaction was quenched with saturated aqueous ammonium chloride solution (500 mL) and water (750 mL) and diluted with ether (~2 L). Separate the organic and aqueous layers and the aqueous layer was then extracted with ether (about 1 L). The organic layers were combined (ca. 5.5 L), dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product 2-chloro-3-methyl-4-fluorobenzonitrile as a reddish brown oily solid (ca. 86.7 g). The crude product was purified by silica gel column chromatography (silica gel column size: 10×30 cm, eluent gradient: 99:1 to 93:7 hexane/ethyl acetate) to afford the pure product 2-chloro-3-methyl-4-fluorobenzonitrile (56.7 g, 76% yield) as a white solid with a melting point of 63-65 ° C; 1H NMR (300 MHz, CDCl3): δ 7.54 (dd. J = 8.6, 5.6 Hz, 1H), 7.08 (dd, J = 8.6, 8.6 Hz, 1H), 2.36 (d, J = 2.4 Hz, 3H).
References
[1] Patent: WO2006/124447, 2006, A2. Location in patent: Page/Page column 45-46
[2] Patent: WO2013/55577, 2013, A1. Location in patent: Page/Page column 24-25
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 2, p. 750 - 755
[4] Patent: WO2004/99144, 2004, A1. Location in patent: Page 25
2-chloro-4-fluoro-3-methylbenzonitrile Preparation Products And Raw materials
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View Lastest Price from 2-chloro-4-fluoro-3-methylbenzonitrile manufacturers
- Product
- 2-chloro-4-fluoro-3-methylbenzonitrile 796600-15-2
- Price
- US $21.00-429.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-03-29
- Product
- 2-Chlor-4-fluor-3-methylbenzonitril 796600-15-2
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 2-Chloro-4-fluoro-3-methylbenzonitrile 796600-15-2
- Price
- US $100.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 10tons
- Release date
- 2023-06-14