N-Boc-3-methyl-4-hydroxypiperidine

Product Name: N-Boc-3-methyl-4-hydroxypiperidine
CAS No.: 181269-70-5
Chemical Name: N-Boc-3-methyl-4-hydroxypiperidine
Synonyms: 1-Boc4-hydroxy-3-Methylpiperidine;N-Boc-3-methyl-4-hydroxypiperidine;tert-Butyl 4-hydroxy-3-Methylpiperidine-1-carboxylate;1,1-Dimethylethyl 4-hydroxy-3-methyl-1-piperidinecarboxylate;4-Hydroxy-3-methyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-hydroxy-3-Methyl-, 1,1-diMethylethylester
CBNumber: CB62473848
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 181269-70-5.mol

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N-Boc-3-methyl-4-hydroxypiperidine Property

Boiling point:: 301.4±35.0 °C(Predicted)
Density: 1.067
storage temp.: Sealed in dry,Room Temperature
pka: 14.83±0.40(Predicted)
Appearance: Colorless to off-white Solid-liquid mixture

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B704220
Product name: tert-butyl4-hydroxy-3-methylpiperidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 9506AA
Product name: 1-Boc4-hydroxy-3-methylpiperidine
Packaging: 1g
Price: $309
Updated: 2021/12/16

Matrix Scientific

Product number: 176405
Product name: tert-Butyl-4-hydroxy-3-methyl-1-piperidinecarboxylate
Packaging: 1g
Price: $432
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0383201
Product name: 4-HYDROXY-3-METHYL-PIPERIDINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $501.91
Updated: 2021/12/16

Matrix Scientific

Product number: 176405
Product name: tert-Butyl-4-hydroxy-3-methyl-1-piperidinecarboxylate
Packaging: 5g
Price: $1206
Updated: 2021/12/16

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N-Boc-3-methyl-4-hydroxypiperidine Chemical Properties,Usage,Production

Synthesis

181269-69-2

181269-70-5

The general procedure for the synthesis of tert-butyl 4-hydroxy-3-methylpiperidine-1-carboxylate from N-Boc-3-methyl-piperidin-4-one was as follows: (i) Sodium borohydride (0.265 g, 7.03 mmol) was added batchwise to a solution of (R,S)-tert-butyl-3-methyl-4-oxopiperidine-1-carboxylate (1.0 g, 4.68 mmol) in methanol (10 mL) at 0 °C. The reaction mixture was kept stirred at 0 °C for 1 hour, then warmed up to room temperature and continued stirring for 2.5 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution and concentrated under reduced pressure to remove methanol. The reaction mixture was extracted with dichloromethane, the organic layers were combined and dried over anhydrous sodium sulfate. After filtration, the organic layer was concentrated under reduced pressure to afford the target product tert-butyl 4-hydroxy-3-methylpiperidine-1-carboxylate as a colorless oil (quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (ES+): 1H NMR δppm 0.87-0.94 (m, 3H), 1.33-1.88 (m, 3H), 1.38 (s, 9H), 2.23-4.08 (m, 5H); MS: ES+ 216.

References

[1] Patent: US2013/324576, 2013, A1. Location in patent: Paragraph 0625; 0626; 0627; 0628
[2] Patent: WO2013/179024, 2013, A1. Location in patent: Page/Page column 56-57
[3] Patent: US2005/182095, 2005, A1. Location in patent: Page/Page column 38
[4] Patent: WO2004/41777, 2004, A2. Location in patent: Page 74-75
[5] Patent: WO2013/96744, 2013, A1. Location in patent: Page/Page column 199

N-Boc-3-methyl-4-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-3-methyl-4-hydroxypiperidine Suppliers

China 41 Germany 1 India 1 United States 3 Global 46

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181269-70-5, N-Boc-3-methyl-4-hydroxypiperidineRelated Search:

4-Hydroxy-3-methyl-piperidine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-hydroxy-3-Methylpiperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-hydroxy-3-Methyl-, 1,1-diMethylethylester

N-Boc-3-methyl-4-hydroxypiperidine

1-Boc4-hydroxy-3-Methylpiperidine

1,1-Dimethylethyl 4-hydroxy-3-methyl-1-piperidinecarboxylate

181269-70-5