Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- Product Name
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- CAS No.
- 959616-64-9
- Chemical Name
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- Synonyms
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate;2-Chloro-5-fluoro-6-methoxy-nicotinic acid methyl ester;Methyl 2-chloro-5-fluoro-6-methoxy-pyridine-3-carboxylate;Methyl 2-chloro-5-fluoro-6-methoxynicotinate ISO 9001：2015 REACH;3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-6-methoxy-, methyl ester;Methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate, 2-Chloro-5-fluoro-6-methoxy-3-(methoxycarbonyl)pyridine
- CBNumber
- CB62481685
- Molecular Formula
- C8H7ClFNO3
- Formula Weight
- 219.6
- MOL File
- 959616-64-9.mol
Methyl 2-chloro-5-fluoro-6-methoxynicotinate Property
- Melting point:
- 66-68°
- Boiling point:
- 279.8±40.0 °C(Predicted)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.47±0.10(Predicted)
- Appearance
- white solid
- InChI
- InChI=1S/C8H7ClFNO3/c1-13-7-5(10)3-4(6(9)11-7)8(12)14-2/h3H,1-2H3
- InChIKey
- KGWMUWXJNVKKCF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(OC)=C(F)C=C1C(OC)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M340418
- Product name
- Methyl2-Chloro-5-fluoro-6-methoxynicotinate
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- Z5414
- Product name
- Methyl2-chloro-5-fluoro-6-methoxynicotinate
- Packaging
- 1g
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 046252
- Product name
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $217
- Updated
- 2021/12/16
- Product number
- 4H23-7-17
- Product name
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate
- Packaging
- 1g
- Price
- $288
- Updated
- 2021/12/16
- Product number
- Z5414
- Product name
- Methyl2-chloro-5-fluoro-6-methoxynicotinate
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
Methyl 2-chloro-5-fluoro-6-methoxynicotinate Chemical Properties,Usage,Production
Synthesis
189281-66-1
124-41-4
959616-64-9
Intermediate 73b: Synthesis of methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate. Sodium methanol (1.86 mL, 11.91 mmol) was added to a solution of toluene (9 mL) containing methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate (1.8 g, 8.03 mmol), and the reaction mixture was stirred for 1 h at room temperature. After completion of the reaction, ethyl acetate (20 mL) and water (20 mL) were added to the mixture to separate the organic and aqueous layers. The aqueous layer was extracted with ethyl acetate (3 x 20 mL), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate (1.72 g, 7.83 mmol, 97% yield) as an orange solid. The product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 7.92 (1H, d, J = 9.6 Hz), 4.09 (3H, s), 3.92 (3H, s). Mass spectrometry analysis (Method 2): retention time 1.71 min, m/z 220.0 [M + H]+.
References
[1] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00667; 00670; 00671
[2] Patent: EP2022793, 2009, A1. Location in patent: Page/Page column 72
Methyl 2-chloro-5-fluoro-6-methoxynicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-chloro-5-fluoro-6-methoxynicotinate manufacturers
- Product
- Methyl 2-chloro-5-fluoro-6-methoxynicotinate 959616-64-9
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02