tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Product Name: tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
CAS No.: 301226-27-7
Chemical Name: tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Synonyms: 8-Boc-1-oxa-8-azaspiro[4.5]decan-2-one;8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane;8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane - X11712;tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;1,1-diMethylethyl 1-oxa-2-oxo-8-azaspiro[4.5]decane-8-carboxylate;2-Oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester;1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester
CBNumber: CB62484464
Molecular Formula: C13H21NO4
Formula Weight: 255.31
MOL File: 301226-27-7.mol

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tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Property

Boiling point:: 399.6±35.0 °C(Predicted)
Density: 1.16±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: -0.84±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 4H56-1-MJ
Product name: 8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 042733
Product name: tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Purity: >95%
Packaging: 500mg
Price: $78
Updated: 2021/12/16

ChemScene

Product number: CS-0000747
Product name: tert-Butyl2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 042733
Product name: tert-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Purity: >95%
Packaging: 1g
Price: $120
Updated: 2021/12/16

Synthonix

Product number: X11712
Product name: 8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane
Purity: 97.0%
Packaging: 1g
Price: $160
Updated: 2021/12/16

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tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Chemical Properties,Usage,Production

Synthesis

374794-91-9

301226-27-7

4-(3-Ethoxy-3-oxopropan-1-yl)-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (27.63 g, 0.092 mol) was used as raw material and dissolved in toluene (250 mL). To this solution was added p-toluenesulfonic acid (1.75 g, 9.2 mmol) and the mixture was heated to reflux for 3 hours. After the reaction was complete, the mixture was cooled and the solvent was removed by evaporation under reduced pressure. Water (400 mL) and ethyl acetate (400 mL) were added to the residue to separate the organic and aqueous layers. The aqueous layer was further extracted with ethyl acetate (200 mL). All organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to afford 1-oxo-8-N-BOC-azaspiro[4.5]decan-2-one (20.86 g, 88% yield). The mass spectrum (electrospray positive ion mode) showed m/z 256 ([M+1]+).

References

[1] Patent: US2003/236250, 2003, A1. Location in patent: Page 29
[2] Patent: WO2004/78750, 2004, A1. Location in patent: Page 79-80
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 13, p. 1759 - 1762

tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate manufacturers

Career Henan Chemical Co

Product: tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 301226-27-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

301226-27-7, tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylateRelated Search:

1,1-diMethylethyl 1-oxa-2-oxo-8-azaspiro[4.5]decane-8-carboxylate

8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane

1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester

2-Oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester

8-Boc-2-oxo-1-oxa-8-azaspiro[4.5]decane - X11712

8-Boc-1-oxa-8-azaspiro[4.5]decan-2-one

<i>tert</i>-Butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

301226-27-7