ChemicalBook > CAS DataBase List > 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

Product Name: 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
CAS No.: 223488-57-1
Chemical Name: 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
Synonyms: CS-2325;CP-533536;Evatanepag;CP-533536 free acid;Evatanepag (CP-533536);Evatanepag, 10 mM in DMSO;CP-533536;CP 533536;CP533536;EVATANEPAG;CP-533536;CP 533536;2-(3-((N-(4-(tert-Butyl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid;2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
CBNumber: CB62484828
Molecular Formula: C25H28N2O5S
Formula Weight: 468.57
MOL File: 223488-57-1.mol

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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO:32.0(Max Conc. mg/mL);68.29(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5571
Product name: Evatanepag
Purity: 99.80%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006002
Product name: CP-533536
Purity: 95.00%
Packaging: 5MG
Price: $497.45
Updated: 2021/12/16

ChemScene

Product number: CS-5571
Product name: Evatanepag
Purity: 99.80%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

AK Scientific

Product number: 4016CR
Product name: Evatanepag
Packaging: 2mg
Price: $611
Updated: 2021/12/16

ChemScene

Product number: CS-5571
Product name: Evatanepag
Purity: 99.80%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Chemical Properties,Usage,Production

Uses

Evatanepag is an EP2 receptor selective prostaglandin E2 agonist that helps induce bone growth.

Definition

ChEBI: Evatanepag is a monocarboxylic acid.

in vivo

Evatanepag (0.3-3.0 mg/kg, directly injected into the marrow cavity of the tibia) promotes bone formation in rats^[1].
Evatanepag (0.3, 3.0 mg/kg, intranasal administration, from day1 to day4) reduces HDM aeroallergen-induced increased RL response to methacholine in mice^[2].
Evatanepag (1 mg/kg, intravenous injection) demonstrates high i.v. clearance (Cl: 56 mL/min/kg) and a short half-life (t_1/2: 0.33 h)^[1].

Animal Model:	Rats^[1]
Dosage:	0.3, 1.0, 3.0 mg/kg
Administration:	Directly injected into the marrow cavity of the tibia
Result:	Dose-dependently increased in bone area, bone mineral content, bone mineral density.

Animal Model:	HDM (house dust mite)-sensitized BALB/c mice^[2]
Dosage:	0.3 mg/kg, 3 mg/kg
Administration:	Intranasal administration, from day1 to day4
Result:	Prevented aeroallergen-driven increased RL (lung resistance) at 0.3 mg/kg. Prevented the enhanced MC activity by approximately 48% at 3 mg/kg.

IC 50

EP2

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid 223488-57-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Career Henan Chemical Co

Product: 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid 223488-57-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

223488-57-1, 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acidRelated Search:

N-Methylformamide

EVATANEPAG;CP-533536;CP 533536

CP-533536;CP 533536;CP533536

(3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid

Evatanepag (CP-533536)

CS-2325

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

CP-533536

Evatanepag

CP-533536 free acid

Acetic acid, 2-[3-[[[[4-(1,1-dimethylethyl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-

2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]aceticaci

2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid ISO 9001：2015 REACH

HDM,asthma,CP533536,mast cell,CP-533536,CP 533536,Evatanepag,bone,Prostaglandin Receptor,Inhibitor,Fracture healing,allergy,inflammation,inhibit

2-(3-((N-(4-(tert-Butyl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid

2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid

Evatanepag, 10 mM in DMSO

223488-57-1