4-(bromomethyl)benzo[d][1,3]dioxole
- Product Name
- 4-(bromomethyl)benzo[d][1,3]dioxole
- CAS No.
- 101417-40-7
- Chemical Name
- 4-(bromomethyl)benzo[d][1,3]dioxole
- Synonyms
- 4-(bromomethyl)-1,3-Benzodioxole;1,3-Benzodioxole, 4-(bromomethyl)-;4-(bromomethyl)benzo[d][1,3]dioxole
- CBNumber
- CB62485294
- Molecular Formula
- C8H7BrO2
- Formula Weight
- 215.04
- MOL File
- 101417-40-7.mol
4-(bromomethyl)benzo[d][1,3]dioxole Property
- Melting point:
- 62-62.5 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 274.8±19.0 °C(Predicted)
- Density
- 1.652±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H7BrO2/c9-4-6-2-1-3-7-8(6)11-5-10-7/h1-3H,4-5H2
- InChIKey
- NXSORIZRMNGQNL-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC(CBr)=C2OC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B679425
- Product name
- 4-(Bromomethyl)benzo[d][1,3]dioxole
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FB141662
- Product name
- 4-(Bromomethyl)benzo[d][1,3]dioxole
- Packaging
- 2g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB141662
- Product name
- 4-(Bromomethyl)benzo[d][1,3]dioxole
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB141662
- Product name
- 4-(Bromomethyl)benzo[d][1,3]dioxole
- Packaging
- 1g
- Price
- $121
- Updated
- 2021/12/16
- Product number
- FB141662
- Product name
- 4-(Bromomethyl)benzo[d][1,3]dioxole
- Packaging
- 10g
- Price
- $456
- Updated
- 2021/12/16
4-(bromomethyl)benzo[d][1,3]dioxole Chemical Properties,Usage,Production
Synthesis
769-30-2
101417-40-7
General procedure: An ethyl ether solution of phosphorus tribromide is prepared by dissolving 3.1 ml (0.033 mol) of phosphorus tribromide in 15 ml of ether. This solution was slowly added dropwise to an ether solution containing 4.5 g (0.03 mol) of 1,3-benzodioxolane-4-alkylmethanol at 0°C in an ice bath. After the dropwise addition was completed, the reaction was continued with stirring at 0°C for 3 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium carbonate solution, the organic phase was separated and washed with saturated sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate for 8 hours and then filtered to remove the desiccant. The filtrate was distilled under reduced pressure to remove the solvent to obtain the crude product. The crude product was purified by fast silica gel column chromatography using petroleum ether: ethyl acetate (19:1) as eluent to give 5.8 g of the yellow oily target product 4-(bromomethyl)benzo[d][1,3]dioxole in 90.6% yield.
References
[1] Australian Journal of Chemistry, 1985, vol. 38, # 10, p. 1481 - 1489
[2] Patent: CN103804341, 2018, B. Location in patent: Paragraph 0064; 0072; 0073
[3] Patent: CN108690016, 2018, A. Location in patent: Paragraph 0555; 0557; 0558
[4] Patent: WO2007/44796, 2007, A2. Location in patent: Page/Page column 108-109
[5] Journal of the American Chemical Society, 1957, vol. 79, p. 6033
4-(bromomethyl)benzo[d][1,3]dioxole Preparation Products And Raw materials
Raw materials
Preparation Products
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