ChemicalBook > CAS DataBase List > 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester

1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester

Product Name
1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester
CAS No.
1003846-21-6
Chemical Name
1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester
Synonyms
EOS-61071;1-(2-Tetrahydropyranyl)-1...;1-(tetrahydro-2H-pyran-2-yl)-4-(4;Pinacol 1-(Oxan-2-yl)-4-pyrazole-boronate;1-(2-Tetrahydropyranyl)pyrazole-4-boronic Acid Pinacol Ester;1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol e...;1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol este;1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester;1-(oxan-2-yl)-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(oxan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
CBNumber
CB62485416
Molecular Formula
C14H23BN2O3
Formula Weight
278.15
MOL File
1003846-21-6.mol
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1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester Property

Melting point:
88-90°
Boiling point:
413.8±35.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
1.95±0.19(Predicted)
color 
White
InChI
InChI=1S/C14H23BN2O3/c1-13(2)14(3,4)20-15(19-13)11-9-16-17(10-11)12-7-5-6-8-18-12/h9-10,12H,5-8H2,1-4H3
InChIKey
YYSLAWXDXHVRHU-UHFFFAOYSA-N
SMILES
N1(C2OCCCC2)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BML00300
Product name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid pinacol ester
Purity
Aldrich
Packaging
1g
Price
$330
Updated
2025/07/31
TRC
Product number
B416178
Product name
1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging
10mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
6H60-1-X8
Product name
1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid, pinacol ester
Purity
97%
Packaging
5G
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-W000826
Product name
1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity
≥98.0%
Packaging
10g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
X4874
Product name
1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronicacidpinacolester
Packaging
5g
Price
$61
Updated
2021/12/16
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1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester Chemical Properties,Usage,Production

Uses

1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research chemical for organic synthesis and other chemical processes.

Synthesis

110-87-2

269410-08-4

1003846-21-6

The general procedure for the synthesis of 1-THP-4-pyrazoleboronic acid pinacol ester from 3,4-dihydro-2H-pyran and 4-pyrazoleboronic acid pinacol ester was as follows: 3,4-dihydro-2H-pyran (5.6 g, 67 mmol) and trifluoroacetic acid (1.17 g, 10.3 mmol) were added to a 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborono pentan-2-yl)-1H-pyrazole (10.0 g, 51.5 mmol) in a solution of toluene (200 mL). The reaction mixture was heated to 90 °C and kept for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was partitioned between ethyl acetate (200 mL) and saturated aqueous sodium bicarbonate solution (100 mL). The aqueous layer was further extracted with ethyl acetate (100 mL). The organic layers were combined, washed with saturated aqueous sodium chloride (100 mL), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. Purification by silica gel column chromatography (elution gradient: 10% to 50% petroleum ether solution of ethyl acetate) afforded the target product 1-THP-4-pyrazoleboronic acid pinacol ester as a white solid. Yield: 13.4 g, 48.2 mmol, 94% yield.1H NMR (400 MHz, CDCl3) δ 7.94 (s, 1H), 7.83 (s, 1H), 5.41 (dd, J = 9.5, 2.5 Hz, 1H), 4.01-4.08 (m, 1H), 3.65-3.74 (m, 1H), 1.98- 2.18 (m, 3H), 1.60-1.76 (m, 3H), 1.32 (s, 12H).

References

[1] Patent: WO2014/1973, 2014, A1. Location in patent: Page/Page column 60; 61; 62
[2] Patent: WO2018/201006, 2018, A1. Location in patent: Paragraph 0125; 0126
[3] Patent: WO2016/210331, 2016, A1. Location in patent: Paragraph 0225; 0226
[4] Patent: WO2016/210330, 2016, A1. Location in patent: Paragraph 0405-0406
[5] Patent: WO2009/71509, 2009, A1. Location in patent: Page/Page column 80-81

1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester Suppliers

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View Lastest Price from 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1003846-21-6
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester 1003846-21-6
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-02
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester 1003846-21-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

1003846-21-6, 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol esterRelated Search:


  • 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester
  • 1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • 1-(2-Tetrahydropyranyl)-1...
  • 1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(SALTDATA: FREE)
  • 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid, pinacol ester
  • 1-(oxan-2-yl)-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • 1-Tetrahydropyran-2-yl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • 1-(tetrahydro-2H-pyran-2-yl)-4-(4
  • 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid, pinacol ester, tech
  • 1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-[1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 1-(Tetrahydro-pyran-2-yl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
  • Pinacol 1-(Oxan-2-yl)-4-pyrazole-boronate
  • 1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleacid,pinacol ester
  • EOS-61071
  • 1-(2-Tetrahydropyranyl)pyrazole-4-boronic Acid Pinacol Ester
  • 1-(oxan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • 1H-Pyrazole, 1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-
  • 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol e...
  • 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol este
  • 1-(Tetrahydro-2<i>H</i>-pyran-2-yl)-1<i>H</i>-pyrazole-4-boronic acid pinacol ester
  • 1-Tetrahydropyran-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole - [T0485]
  • 1003846-21-6