1-Methylindazole-6-carboxylic acid

Product Name: 1-Methylindazole-6-carboxylic acid
CAS No.: 1031417-77-2
Chemical Name: 1-Methylindazole-6-carboxylic acid
Synonyms: 1-Methylindazole-6-carboxylic acid;1-Methyl-1H-indazol-6-carboxylic acid;1H-Indazole-6-carboxylic acid, 1-methyl-
CBNumber: CB62485456
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 1031417-77-2.mol

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1-Methylindazole-6-carboxylic acid Property

Boiling point:: 383.7±15.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at room temperature
pka: 4.10±0.30(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M219555
Product name: 1-Methyl-1H-indazole-6-carboxylicAcid
Packaging: 1g
Price: $330
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-G1
Product name: 1-Methylindazole-6-carboxylic acid
Packaging: 1g
Price: $225
Updated: 2021/12/16

AK Scientific

Product number: Y6858
Product name: 1-Methyl-1H-indazole-6-carboxylicacid
Packaging: 1g
Price: $251
Updated: 2021/12/16

AK Scientific

Product number: Y6858
Product name: 1-Methyl-1H-indazole-6-carboxylicacid
Packaging: 250mg
Price: $131
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0385680
Product name: 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $505.76
Updated: 2021/12/16

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1-Methylindazole-6-carboxylic acid Chemical Properties,Usage,Production

Synthesis

1007219-73-9

74-88-4

1031417-77-2

General procedure for the synthesis of 1-methyl-1H-indazole-6-carboxylic acid from methyl 1-methyl-1H-indazole-6-carboxylate and iodomethane: 1H-indazole-6-carboxylic acid methyl ester was prepared with reference to the methodology reported in J. Med. Chem. 2000,43(1),41-58 (Example 12b, p. 49). Subsequently, methyl 1-methyl-1H-indazole-6-carboxylate was obtained in 43% yield under standard alkylation conditions (using sodium hexamethyldisilamate as base, THF as solvent, and iodomethane as alkylation reagent, and refluxing the reaction mixture). Finally, the above esters were treated under standard saponification conditions (1N NaOH aqueous solution) to obtain the target product 1-methyl-1H-indazole-6-carboxylic acid in 96% yield.

References

[1] Patent: WO2008/65508, 2008, A1. Location in patent: Page/Page column 34

1-Methylindazole-6-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methylindazole-6-carboxylic acid Suppliers

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1031417-77-2, 1-Methylindazole-6-carboxylic acidRelated Search:

1-Methylindazole-6-carboxylic acid

1-Methyl-1H-indazol-6-carboxylic acid

1H-Indazole-6-carboxylic acid, 1-methyl-

1031417-77-2