1-Methylindazole-6-carboxylic acid
- Product Name
- 1-Methylindazole-6-carboxylic acid
- CAS No.
- 1031417-77-2
- Chemical Name
- 1-Methylindazole-6-carboxylic acid
- Synonyms
- 1-Methylindazole-6-carboxylic acid;1-Methyl-1H-indazol-6-carboxylic acid;1H-Indazole-6-carboxylic acid, 1-methyl-
- CBNumber
- CB62485456
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 1031417-77-2.mol
1-Methylindazole-6-carboxylic acid Property
- Boiling point:
- 383.7±15.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 4.10±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M219555
- Product name
- 1-Methyl-1H-indazole-6-carboxylicAcid
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 4H58-1-G1
- Product name
- 1-Methylindazole-6-carboxylic acid
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- Y6858
- Product name
- 1-Methyl-1H-indazole-6-carboxylicacid
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- Y6858
- Product name
- 1-Methyl-1H-indazole-6-carboxylicacid
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- CHM0385680
- Product name
- 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.76
- Updated
- 2021/12/16
1-Methylindazole-6-carboxylic acid Chemical Properties,Usage,Production
Synthesis
1007219-73-9
74-88-4
1031417-77-2
General procedure for the synthesis of 1-methyl-1H-indazole-6-carboxylic acid from methyl 1-methyl-1H-indazole-6-carboxylate and iodomethane: 1H-indazole-6-carboxylic acid methyl ester was prepared with reference to the methodology reported in J. Med. Chem. 2000,43(1),41-58 (Example 12b, p. 49). Subsequently, methyl 1-methyl-1H-indazole-6-carboxylate was obtained in 43% yield under standard alkylation conditions (using sodium hexamethyldisilamate as base, THF as solvent, and iodomethane as alkylation reagent, and refluxing the reaction mixture). Finally, the above esters were treated under standard saponification conditions (1N NaOH aqueous solution) to obtain the target product 1-methyl-1H-indazole-6-carboxylic acid in 96% yield.
References
[1] Patent: WO2008/65508, 2008, A1. Location in patent: Page/Page column 34
1-Methylindazole-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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