ChemicalBook > CAS DataBase List > 1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one

1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one

Product Name
1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
CAS No.
185961-99-3
Chemical Name
1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Synonyms
Rimegepant Impurity 59;1-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-2-one;1-(4-Piperidyl)imidazo[4,5-b]pyridin-2(3H)-one;1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one;1-Piperidin-4-yl-1,3-dihydro-iMidazo[4,5-b]pyridin-2-one;1,3-dihydro-1-(4-piperidinyl)-2h-imidazo[4,5-b]pyridin-2-one;1-(Piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;2H-IMidazo[4,5-b]pyridin-2-one, 1,3-dihydro-1-(4-piperidinyl)-
CBNumber
CB62487687
Molecular Formula
C11H14N4O
Formula Weight
218.26
MOL File
185961-99-3.mol
More
Less

1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

AK Scientific
Product number
9717AA
Product name
1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Packaging
100mg
Price
$215
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0385602
Product name
1-(PIPERIDIN-4-YL)-1H-IMIDAZO-[4,5-B]PYRIDIN-2(3H)-ONE
Purity
95.00%
Packaging
5MG
Price
$498.16
Updated
2021/12/16
Ambeed
Product number
A495925
Product name
1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Purity
95+%
Packaging
100mg
Price
$88
Updated
2021/12/16
Alichem
Product number
185961993
Product name
1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Packaging
250mg
Price
$202.8
Updated
2021/12/16
Ambeed
Product number
A495925
Product name
1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Purity
95+%
Packaging
250mg
Price
$213
Updated
2021/12/16
More
Less

1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one Chemical Properties,Usage,Production

Synthesis

1146637-16-2

185961-99-3

Step 4: 690 g (1.96 mol) of benzyl 4-(2-oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate was dissolved in 5.4 L of methanol, heated to 60 °C and 46 g of 10% Pd/C catalyst was added (catalyst-to-substrate mass ratio of 6.6%). The hydrogenation reaction was carried out under 60 psi hydrogen pressure until hydrogen absorption was complete. Upon completion of the reaction, the catalyst was removed by filtration. 4 L of methanol was removed by distillation from the filtrate, followed by the addition of 2 L of methylcyclohexane and continued distillation to remove 1.5 L of solvent. The resulting suspension was diafiltrated and the residue was washed with methylcyclohexane and dried at 40 °C. Yield: 446 g (100%). eSI-MS: m/z = 219 (M + H)+.

References

[1] Patent: US2010/324028, 2010, A1. Location in patent: Page/Page column 32
[2] Patent: US2011/59954, 2011, A1. Location in patent: Page/Page column 67
[3] Patent: US2011/195954, 2011, A1. Location in patent: Page/Page column 75
[4] Patent: US2012/88755, 2012, A1. Location in patent: Page/Page column 51-52

1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one Suppliers

China 41 India 1 United States 5 Global 47
Shanghai Xiannuo Biotechnology Co., Ltd.
Tel
021-50718719 13918719472
Fax
021-50718719
Country
China
ProdList
979
Advantage
58
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shandong Boluoda Biological Technology Co., Ltd.
Tel
0531-68652053 15863796298;
Email
2310993908@qq.com
Country
China
ProdList
2437
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Tcichem, Inc.
Tel
13918644899
Fax
-
Email
tianchong009@hotmail.com
Country
China
ProdList
1818
Advantage
55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4941
Advantage
55

185961-99-3, 1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-oneRelated Search:


  • 1-(piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
  • 2H-IMidazo[4,5-b]pyridin-2-one, 1,3-dihydro-1-(4-piperidinyl)-
  • 1-Piperidin-4-yl-1,3-dihydro-iMidazo[4,5-b]pyridin-2-one
  • 1-(Piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
  • 1,3-dihydro-1-(4-piperidinyl)-2h-imidazo[4,5-b]pyridin-2-one
  • Rimegepant Impurity 59
  • 1-(4-Piperidyl)imidazo[4,5-b]pyridin-2(3H)-one
  • 1-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-2-one
  • 185961-99-3