ChemicalBook > CAS DataBase List > 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

Product Name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
CAS No.: 1053228-28-6
Chemical Name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms: EOS-60657;cas no 1053228-28-6;cas no 1053228-28-6 for sale;cas no 1053228-28-6 price USD;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro-;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid, 10 mM in DMSO;2,4,5Trichloro7Hpyrrolo[2,3d]pyrimid,2,4,5 Trichloro 7H pyrrolo[2,3 d]pyrimid
CBNumber: CB62489641
Molecular Formula: C6H2Cl3N3
Formula Weight: 222.46
MOL File: 1053228-28-6.mol

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2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Property

Melting point:: 225 °C(Solv: dichloromethane (75-09-2))
Density: 1.791±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.69±0.50(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T774213
Product name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: T774213
Product name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 500mg
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362612
Product name: 2,4,5-TRICHLORO-7H-PYRROLO-[2,3-D]PYRIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.67
Updated: 2021/12/16

ChemScene

Product number: CS-W003858
Product name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
Purity: 97.13%
Packaging: 25g
Price: $550
Updated: 2021/12/16

AK Scientific

Product number: X8750
Product name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 100mg
Price: $131.6
Updated: 2021/12/16

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2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

90213-66-4

1053228-28-6

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (2.0 g, 10.64 mmol) was used as a starting material, which was dissolved in dichloromethane/tetrahydrofuran (DCM/THF, 15 mL/6 mL) mixed solvent. Subsequently, N-chlorosuccinimide (NCS, 1.70 g, 12.76 mmol) was added to the solution. The reaction mixture was placed in a microwave reactor, heated to 90 °C and kept at this temperature for 2.5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by fast column chromatography with the eluent being a 9:1 (v/v) hexane/ethyl acetate solvent mixture to afford 2,4,5-trichloro-7H-pyrrolo[2,3-d]pyrimidine (2.2 g, 93% yield) as a white crystalline solid. Mass spectrometry (MS) analysis showed m/z 223.48 [M + 1].

References

[1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 584 - 589
[3] Patent: WO2016/130920, 2016, A2. Location in patent: Page/Page column 115
[4] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 127
[5] Organic Letters, 2016, vol. 18, # 9, p. 1976 - 1979

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyriMidine 1053228-28-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine 1053228-28-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-08

1053228-28-6, 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidineRelated Search:

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cas no 1053228-28-6

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid, 10 mM in DMSO

1053228-28-6

pyrimidine

Heterocycle-Pyrimidine series