2-amino-6-bromo-5-methylpyrazine
- Product Name
- 2-amino-6-bromo-5-methylpyrazine
- CAS No.
- 74290-68-9
- Chemical Name
- 2-amino-6-bromo-5-methylpyrazine
- Synonyms
- 106812;6-broMo-5-Methylpyrazin-2-aMine;2-amino-6-bromo-5-methylpyrazine;2-Pyrazinamine, 6-bromo-5-methyl-
- CBNumber
- CB62490272
- Molecular Formula
- C5H6BrN3
- Formula Weight
- 188.03
- MOL File
- 74290-68-9.mol
2-amino-6-bromo-5-methylpyrazine Property
- Melting point:
- 154-157 °C
- Boiling point:
- 290.8±35.0 °C(Predicted)
- Density
- 1.699±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.17±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B814265
- Product name
- 6-bromo-5-methylpyrazin-2-amine
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 1542AC
- Product name
- 6-Bromo-5-methylpyrazin-2-amine
- Packaging
- 250mg
- Price
- $188
- Updated
- 2021/12/16
- Product number
- HCH0098864
- Product name
- 2-AMINO-6-BROMO-5-METHYLPYRAZINE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $726
- Updated
- 2021/12/16
- Product number
- 1542AC
- Product name
- 6-Bromo-5-methylpyrazin-2-amine
- Packaging
- 5g
- Price
- $1427
- Updated
- 2021/12/16
- Product number
- HCH0098864
- Product name
- 2-AMINO-6-BROMO-5-METHYLPYRAZINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1443.75
- Updated
- 2021/12/16
2-amino-6-bromo-5-methylpyrazine Chemical Properties,Usage,Production
Synthesis
5521-58-4
74290-65-6
74290-68-9
General procedure for the synthesis of 2-amino-3-bromo-5-methylpyrazine and 2-amino-6-bromo-5-methylpyrazine from 2-amino-5-methylpyrazine: over 15 min, HBr/CH3CO2H solution (360 g (260 mL), 1.50 mol, 33% HBr in CH3CO2H solution) in anhydrous CHCl3 (300 mL) was was slowly added to a solution of CHCl3 (1 L) containing 5-methylpyrazin-2-amine (42 g, 0.38 mmol). The reaction flask was wrapped in aluminum foil to protect it from light and heated at 50 °C for 30 min. Subsequently, a CHCl3 (500 mL) solution of Br2 (68 g, 0.42 mmol) was added dropwise over a period of 3 h, during which time the internal temperature of the reaction was ensured not to exceed 55 °C. The reaction was continued stirring at 55 °C for 18 h before evaporating the solvent under reduced pressure. The crude product was diluted with water (200 mL) and the pH was adjusted to 9 by the addition of solid Na2CO3. The suspension was vacuum filtered and the filtrate was extracted with EtOAc (1L x 5). The organic phases were combined, concentrated under reduced pressure and purified by fast silica gel chromatography with the eluent petroleum ether/EtOAc (5:1→1:1) to afford 6-bromo-5-methylpyrazin-2-amine (36 g, 50%) as a light orange solid with melting point of 154-157 °C. IR (KBr): 3315, 3188, 1744, 1638, 1575, 1482, 1375, 1308, 1051 cm-1; 1H NMR (400MHz, CDCl3): δ=7.84 (s, 1H), 4.55 (br s, 2H), 2.52 (s, 3H); 13C NMR (100MHz, CDCl3): δ=152.2, 141.8, 138.4, 129.2, 22.2; HRMS-ESI: C5H7BrN3 (M+H)+ Calculated values: 187.9823 and 189.9803; Measured values: 187.9816 and 189.9796. 3-bromo-5-methylpyrazin-2-amine analytical samples were also isolated for spectroscopic analysis, melting point 56-57°C. 1H NMR (400MHz, CDCl3): δ=7.80 (s, 1C). 7.80 (s, 1H), 4.95 (br s, 2H), 2.38 (s, 3H); 13C NMR (100MHz, CDCl3): δ=150.6, 142.8, 139.9, 125.2, 19.7; HRMS-ESI: C5H7BrN3 (M+H)+ Calculated values: 187.9823 and 189.9803; measured values: 187.9817 and 189.9796.
References
[1] Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 143 - 147
[2] Tetrahedron, 2011, vol. 67, # 47, p. 9063 - 9066
2-amino-6-bromo-5-methylpyrazine Preparation Products And Raw materials
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