ChemicalBook > CAS DataBase List > 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid

2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid

Product Name: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
CAS No.: 487-66-1
Chemical Name: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
Synonyms: 2-propionic-3-methylmaleic anhydride;2-(2-Carboxyethyl)-3-methylmaleic Anhydride;3-(4-methyl-2,5-dioxo-3-furyl)propanoic acid;3-(4-methyl-2,5-dioxofuran-3-yl)propanoic acid;2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid;3-Furanpropanoic acid, 2,5-dihydro-4-methyl-2,5-dioxo-;2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoicAcid>3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid;3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid (Related Reference)
CBNumber: CB62491082
Molecular Formula: C8H8O5
Formula Weight: 184.15
MOL File: 487-66-1.mol

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2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid Property

Melting point:: 97.0 to 101.0 °C
Boiling point:: 391.0±25.0 °C(Predicted)
Density: 1.408±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 4.31±0.10(Predicted)
color: White to Almost white

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Safety

HS Code: 2932.19.5100

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3955
Product name: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $209
Updated: 2025/07/31

TCI Chemical

Product number: D3955
Product name: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $834
Updated: 2025/07/31

TRC

Product number: D680028
Product name: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 5366AL
Product name: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid
Packaging: 250mg
Price: $139
Updated: 2021/12/16

Ambeed

Product number: A664682
Product name: 3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoicacid
Purity: 95%
Packaging: 250mg
Price: $38
Updated: 2021/12/16

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2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid Chemical Properties,Usage,Production

Synthesis

13192-04-6

3699-66-9

487-66-1

Example 4: Synthesis of Masking Agent A - Preparation of 2-propanoic acid-3-methylmaleic anhydride (carboxydimethylmaleic anhydride or CDM) precursor 1. Suspend sodium hydride (0.58 g, 25 mmol) in 50 mL of anhydrous tetrahydrofuran to which triethyl 2-phosphonopropyl ester (7.1 g, 30 mmol) was added. After the hydrogen release stopped, dimethyl α-ketoglutarate (15 g, 20 mmol) dissolved in 10 mL of anhydrous tetrahydrofuran was added and the reaction mixture was stirred for 30 minutes. 2. Upon completion of the reaction, 10 mL of water was added and the tetrahydrofuran was removed by rotary evaporation. The resulting solid-water mixture was extracted with ether (3 x 50 mL). The ether layers were combined, dried with magnesium sulfate and concentrated to give a light yellow oil. 3. The above oil was purified by silica gel column chromatography with the eluent of ether:hexane (2:1) to give 4 g of pure triglyceride (82% yield). 4. The resulting triglyceride was dissolved in 50 mL of a solvent mixture of water and ethanol (ratio 50:150) and potassium hydroxide (4.5 g, 5 eq.) was added. The reaction mixture was heated to reflux for 1 hour. 5. Upon completion of the reaction, the ethanol was removed by rotary evaporation and the solution was acidified with hydrochloric acid to pH 2. Subsequently, the aqueous solution was extracted with ethyl acetate (200 mL), the organic layer was separated, dried with magnesium sulfate and concentrated to give a white solid. 6. Finally, the white solid was recrystallized by dichloromethane and hexane to give 2 g of 2-propanoic acid-3-methylmaleic anhydride (80% yield).

References

[1] Patent: US9249179, 2016, B2. Location in patent: Page/Page column 35; 36

2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid 487-66-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-10-14

487-66-1, 2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic AcidRelated Search:

2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoic Acid

3-(4-Methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid

2-propionic-3-methylmaleic anhydride

3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoic acid (Related Reference)

2-(2-Carboxyethyl)-3-methylmaleic Anhydride

2,5-Dihydro-4-methyl-2,5-dioxo-3-furanpropanoicAcid&gt

3-Furanpropanoic acid, 2,5-dihydro-4-methyl-2,5-dioxo-

3-(4-methyl-2,5-dioxo-3-furyl)propanoic acid

3-(4-methyl-2,5-dioxofuran-3-yl)propanoic acid

487-66-1