ChemicalBook > CAS DataBase List > oglemilast

oglemilast

Product Name
oglemilast
CAS No.
778576-62-8
Chemical Name
oglemilast
Synonyms
GRC 3886;oglemilast;GRC 3886;GRC-3886;GRC3886;oglemilast ISO 9001：2015 REACH;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carb;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxa;N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide;1-Dibenzofurancarboxamide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-8-[(methylsulfonyl)amino]-;N-(3,5-Dichloropyridin-4-yl)-4-difluoromethoxy-8-[(methylsulfonyl)amino]dibenzo[b,d]furan-1-carboxamide;4-DifluoroMethoxy-8-MethanesulfonylaMino-dibenzofuran-1-carboxylic acid (3,5-dichloro-pyridin-4-yl)-aMide
CBNumber
CB62498829
Molecular Formula
C20H13Cl2F2N3O5S
Formula Weight
516.3
MOL File
778576-62-8.mol
More
Less

oglemilast Property

Density 
1.653
storage temp. 
Store at -20°C
solubility 
DMSO : 4 mg/mL (7.75 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
pka
7.10±0.30(Predicted)
color 
Light yellow to khaki
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FO65110
Product name
Oglemilast
Packaging
5mg
Price
$135
Updated
2021/12/16
ChemScene
Product number
CS-0844
Product name
Oglemilast
Purity
98.20%
Packaging
5mg
Price
$182
Updated
2021/12/16
ChemScene
Product number
CS-0844
Product name
Oglemilast
Purity
98.20%
Packaging
10mg
Price
$307
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0019504
Product name
N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)-8-(METHYLSULFONAMIDO)DIBENZO[B,D]FURAN-1-CARBOXAMIDE
Purity
95.00%
Packaging
5MG
Price
$503.92
Updated
2021/12/16
ChemScene
Product number
CS-0844
Product name
Oglemilast
Purity
98.20%
Packaging
50mg
Price
$612
Updated
2021/12/16
More
Less

oglemilast Chemical Properties,Usage,Production

Uses

Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases[1][2][3].

target

PDE4

IC 50

PDE4D3: .5 nM (IC50)

References

[1] Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. DOI:10.1038/bjp.2008.297
[2] Rabe KF, et al. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol. 2011 May;163(1):53-67. DOI:10.1111/j.1476-5381.2011.01218.x
[3] Wunder F, et al. Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter celllines. Mol Pharm. 2013 Oct 7;10(10):3697-705. DOI:10.1021/mp400206m

oglemilast Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

oglemilast Suppliers

China 66 United Kingdom 3 United States 7 Global 76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1010
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
10524
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Shanghai Zhongzechuan Pharmaceutical Technology Co., LTD
Tel
021-25888888 15021253307
Email
sales@wesyntech.com
Country
China
ProdList
479
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
9898
Advantage
58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
19353112242
Email
1816280386@qq.com
Country
China
ProdList
8045
Advantage
58
Auonsi (Shanghai) Biology Technology Co., Ltd.
Tel
400-1107768 15058188853
Fax
0571-88150696
Email
478133536@qq.com
Country
China
ProdList
8552
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
029-81145305 17791533577
Email
1021@dideu.com
Country
China
ProdList
10009
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Anhui JYHX CO., LTD.
Tel
0551-68788198 13295518198
Email
wangyanan@ahjyhx.com
Country
China
ProdList
1759
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Changzhou Jiezhan Chemical Technology Co., Ltd
Tel
15861130028
Email
song.kevin@howrichworld.com
Country
China
ProdList
412
Advantage
58
ANHUI BYERSEN BIOTECH CO. LTD
Tel
+86-15385096007 +86-17755058861
Email
amy@byersenchemical.com
Country
China
ProdList
10000
Advantage
58
Guangzhou Junuo Biotechnology Co., Ltd.
Tel
13432975901
Country
CHINA
ProdList
132
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Wuhan Boot Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6829
Advantage
58
Shanghai Caiyou Industrial Co., Ltd.
Tel
--
Fax
--
Email
15821073967@163.com
Country
CHINA
ProdList
6748
Advantage
58
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6757
Advantage
58
Shanghai yiji industries Co., Ltd.
Tel
--
Fax
--
Email
yiji01@foxmail.com
Country
China
ProdList
6021
Advantage
50
Shanghai Yuda Industrial Co., Ltd.
Tel
--
Fax
--
Email
lucy@runwelltac.com
Country
CHINA
ProdList
6448
Advantage
58
Shanghai Yihui Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
yihbio@163.com
Country
CHINA
ProdList
6184
Advantage
58
Shanghai Yuqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
847627550@qq.com
Country
CHINA
ProdList
6087
Advantage
58
Shanghai Benrui Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
john.st@163.com
Country
CHINA
ProdList
2160
Advantage
58
Rhenbo (Shanghai) Biochemical Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6333
Advantage
58
Beijing Luyuan Bird Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15810802415@139.com
Country
CHINA
ProdList
6750
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
--
Fax
--
Email
kexianxun@gmail.com
Country
China
ProdList
1037
Advantage
50
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
More
Less

View Lastest Price from oglemilast manufacturers

Dideu Industries Group Limited
Product
oglemilast 778576-62-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-07

778576-62-8, oglemilastRelated Search:


  • GRC 3886
  • oglemilast
  • 4-DifluoroMethoxy-8-MethanesulfonylaMino-dibenzofuran-1-carboxylic acid (3,5-dichloro-pyridin-4-yl)-aMide
  • N-(3,5-Dichloropyridin-4-yl)-4-difluoromethoxy-8-[(methylsulfonyl)amino]dibenzo[b,d]furan-1-carboxamide
  • N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxa
  • N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide
  • N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carb
  • GRC 3886;GRC-3886;GRC3886
  • 1-Dibenzofurancarboxamide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-8-[(methylsulfonyl)amino]-
  • oglemilast ISO 9001：2015 REACH
  • 778576-62-8
  • C20H13Cl2F2N3O5S