6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Product Name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- CAS No.
- 1245644-42-1
- Chemical Name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Synonyms
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 6-bromo-3-iodo-
- CBNumber
- CB62500133
- Molecular Formula
- C6H3BrIN3
- Formula Weight
- 323.92
- MOL File
- 1245644-42-1.mol
6-Bromo-3-iodoimidazo[1,2-a]pyrazine Property
- Density
- 2.64
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.05±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B688908
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 074798
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $148
- Updated
- 2021/12/16
- Product number
- X9587
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- 074798
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $459
- Updated
- 2021/12/16
- Product number
- 074798
- Product name
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $689
- Updated
- 2021/12/16
6-Bromo-3-iodoimidazo[1,2-a]pyrazine Chemical Properties,Usage,Production
Synthesis
912773-24-1
1245644-42-1
General procedure for the synthesis of 6-bromo-3-iodoimidazo[1,2-a]pyrazines from 2-bromoimidazo[1,2-a]pyrazines: 6-bromoimidazo[1,2-a]pyrazines (500 mg, 2.52 mmol) and N-iodosuccinimide (NIS, 852 mg, 3.79 mmol) were dissolved in N,N-dimethylformamide (DMF, 10 mL) in N,N-dimethylformamide (DMF, 10 mL), and after degassing, the reaction mixture was heated to 60 °C and kept for 10 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with dichloromethane (DCM). The organic phase was washed sequentially with aqueous sodium thiosulfate (Na2S2O3) and saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After concentration, the crude product was purified by column chromatography (petroleum ether: ethyl acetate = 5:1) to afford 6-bromo-3-iodoimidazo[1,2-a]pyrazine (530 mg, 65% yield). The product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 8.75 (s, 1H), 8.18 (s, 1H), 7.82 (s, 1H). Mass spectrometry (MS) analysis showed (M+H)+: 324/326.
References
[1] Patent: WO2013/34048, 2013, A1. Location in patent: Page/Page column 74; 75
[2] Patent: EP2818471, 2014, A1. Location in patent: Paragraph 0191; 0192
6-Bromo-3-iodoimidazo[1,2-a]pyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-3-iodoimidazo[1,2-a]pyrazine manufacturers
- Product
- 6-Bromo-3-iodoimidazo[1,2-a]pyrazine 1245644-42-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03