ethyl quinoline-2-carboxylate
- Product Name
- ethyl quinoline-2-carboxylate
- CAS No.
- 4491-33-2
- Chemical Name
- ethyl quinoline-2-carboxylate
- Synonyms
- ethyl quinoline-2-carboxylate;Ethyl quinoline-2-carboxylic acid;2-Quinoline carbocylic acid ethyl ester;2-Quinolinecarboxylic acid, ethyl ester
- CBNumber
- CB62500355
- Molecular Formula
- C12H11NO2
- Formula Weight
- 201.22
- MOL File
- 4491-33-2.mol
ethyl quinoline-2-carboxylate Property
- Melting point:
- 30-33 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 180 °C(Press: 14 Torr)
- Density
- 1.175±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.07±0.40(Predicted)
- Appearance
- Light yellow to yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E932025
- Product name
- Ethylquinoline-2-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y9139
- Product name
- Ethylquinoline-2-carboxylate
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- Y9139
- Product name
- Ethylquinoline-2-carboxylate
- Packaging
- 250mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- CHM0307665
- Product name
- ETHYL QUINOLINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.61
- Updated
- 2021/12/16
- Product number
- A202390
- Product name
- Ethylquinoline-2-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $11
- Updated
- 2021/12/16
ethyl quinoline-2-carboxylate Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Synthesis
93-10-7
75-03-6
4491-33-2
General procedure for the synthesis of ethyl 2-quinolinecarboxylate (6) from quinaldic acid (5) (2.0 g, 11.55 mmol) and ethyl iodide: quinaldic acid (5), dry K2CO3 (3.19 g, 23.10 mmol) and anhydrous DMF (24 mL) were mixed and stirred under argon protection until completely dissolved. Ethyl iodide (2.77 mL, 34.65 mmol) was then added and the reaction was stirred at 60 °C for 18 hours. After completion of the reaction, 30% cooled aqueous HCl solution (30 mL) was added for acidification. The reaction mixture was neutralized with saturated NaHCO3 solution until gas production stopped. The reaction mixture was extracted with ethyl acetate (3 x 60 mL). The organic phases were combined, washed with brine (30 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with hexane/ethyl acetate (8:2) as eluent to give ethyl 2-quinolinecarboxylate (6) as a translucent oil in quantitative yield. the TLC Rf value was 0.51 (hexane/ethyl acetate 7:3). νmax/cm-1 by IR (pure): 3061, 2982, 2938, 2904, 1714, 1463. 1368, 1312, 1133, 1103, 1016, 844, 774.1H NMR (400MHz, CDCl3) δ 7.96-7.94 (m, 1H), 7.85-7.81 (m, 1H), 7.76-7.73 (m, 1H), 7.42-7.36 (m, 2H), 7.22-7.18 (m, 1H), 4.22-7.18 (m, 1H). 1H), 4.22-4.17 (m, 2H), 1.14-1.10 (m, 3H).13C NMR (100 MHz, CDCl3) δ 164.9, 147.9, 147.2, 136.8, 130.3, 129.8, 128.9, 128.1, 127.2, 120.6, 61.7, 14.1. HRMS (ESI+) calculated value C12H11NO2 [M+H]+ 202.0868, measured value 202.0868.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 33, p. 3311 - 3315
ethyl quinoline-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl quinoline-2-carboxylate manufacturers
- Product
- Ethyl 2-quinolinecarboxylate 4491-33-2
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2020-01-09